False-positive bone metastases on PET/CT secondary to sarcoidosis in a patient with rectal cancer

Kenneth M. Montini, Mark Tulchinsky

Research output: Contribution to journalArticle

7 Scopus citations


Patient with newly diagnosed rectal cancer underwent staging PET/CT that showed an intensely [F-18]-fluoro-2-deoxy-D-glucose (FDG)-avid rectal tumor, but also multifocal, intensely FDG-avid mediastinal lymphadenopathy and skeletal foci. The bone foci had no corresponding lytic or blastic lesions on CT. There were mildly FDG-avid reticulonodular opacities in both lungs. This apparent metastatic distribution pattern was highly atypical for rectal cancer; therefore, biopsy was recommended. It showed granulomatous disease in a lymph node and the bone marrow, indicating sarcoidosis. Bone involvement in sarcoidosis is rare, but can lead to the false-positive appearance of metastatic disease on PET/CT.

Original languageEnglish (US)
Pages (from-to)307-310
Number of pages4
JournalClinical nuclear medicine
Issue number3
Publication statusPublished - Mar 1 2012


All Science Journal Classification (ASJC) codes

  • Radiology Nuclear Medicine and imaging

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