Familial syndromes with skin tumor markers

Randy Hauck, E. K. Manders

Research output: Contribution to journalReview article

15 Citations (Scopus)

Abstract

A number of interesting syndromes have been described in which skin tumors are markers of heritable disorders. In Cowden's disease, Muir-Torre's syndrome, and Gardner's syndrome, benign skin tumors accompany and sometimes precede the development of internal visceral malignancy. The association of skin cancers with other abnormalities is found in nevoid basal cell carcinoma syndrome. Bazex syndrome, Rombo syndrome, xeroderma pigmentosum, dysplastic nevus syndrome, and epidermodysplasia verruciformis. Other genetic syndromes in which benign skin tumors herald the existence of systemic diseases include neurofibromatosis, tuberous sclerosis, Haber's syndrome, and Buschke- Ollendorff syndrome. Diagnosis of one of these syndromes may be ascertained by taking a thorough family history. Recognition of the skin tumor may trigger the proper questions regarding family medical history. Diagnosis hinges upon the physician having a high enough index of suspicion to link the appearance of the skin lesions to the diverse manifestations accompanying these disorders. Recognition will also set the stage for appropriate genetic counseling.

Original languageEnglish (US)
Pages (from-to)102-111
Number of pages10
JournalAnnals of Plastic Surgery
Volume33
Issue number1
DOIs
StatePublished - Jan 1 1994

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Tumor Biomarkers
Skin
Neoplasms
Muir-Torre Syndrome
Medical History Taking
Epidermodysplasia Verruciformis
Gardner Syndrome
Multiple Hamartoma Syndrome
Dysplastic Nevus Syndrome
Basal Cell Nevus Syndrome
Xeroderma Pigmentosum
Neurofibromatoses
Tuberous Sclerosis
Genetic Counseling
Skin Neoplasms
Physicians

All Science Journal Classification (ASJC) codes

  • Surgery

Cite this

Hauck, Randy ; Manders, E. K. / Familial syndromes with skin tumor markers. In: Annals of Plastic Surgery. 1994 ; Vol. 33, No. 1. pp. 102-111.
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Familial syndromes with skin tumor markers. / Hauck, Randy; Manders, E. K.

In: Annals of Plastic Surgery, Vol. 33, No. 1, 01.01.1994, p. 102-111.

Research output: Contribution to journalReview article

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