Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology consortium

Eva Negri, Paolo Boffetta, Julien Berthiller, Xavier Castellsague, Maria Paula Curado, Luigino Dal Maso, Alexander W. Daudt, Eleonora Fabianova, Leticia Fernandez, Victor Wünsch-Filho, Silvia Franceschi, Richard B. Hayes, Rolando Herrero, Sergio Koifman, Philip Lazarus, Juan J. Lence, Fabio Levi, Dana Mates, Elena Matos, Ana MenezesJoshua Muscat, Jose Eluf-Neto, Andrew F. Olshan, Peter Rudnai, Oxana Shangina, Erich M. Sturgis, Neonilia Szeszenia-Dabrowska, Renato Talamini, Qingyi Wei, Deborah M. Winn, David Zaridze, Jolanta Lissowska, Zuo Feng Zhang, Gilles Ferro, Paul Brennan, Carlo La Vecchia, Mia Hashibe

Research output: Contribution to journalArticle

82 Citations (Scopus)

Abstract

Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC OR = 1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR = 2.2, 95% CI 1.6-3.1) rather than a parent (OR = 1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR = 1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR = 1.3, 95% CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR = 1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.

Original languageEnglish (US)
Pages (from-to)394-401
Number of pages8
JournalInternational Journal of Cancer
Volume124
Issue number2
DOIs
StatePublished - Jan 15 2009

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Head and Neck Neoplasms
Epidemiology
Odds Ratio
Neoplasms
Tobacco
Alcohols
Hypopharynx
Laryngeal Neoplasms
Tobacco Use
Genetic Predisposition to Disease
Larynx
Alcohol Drinking
Case-Control Studies
Epidemiologic Studies
Confidence Intervals

All Science Journal Classification (ASJC) codes

  • Oncology
  • Cancer Research

Cite this

Negri, E., Boffetta, P., Berthiller, J., Castellsague, X., Curado, M. P., Maso, L. D., ... Hashibe, M. (2009). Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology consortium. International Journal of Cancer, 124(2), 394-401. https://doi.org/10.1002/ijc.23848
Negri, Eva ; Boffetta, Paolo ; Berthiller, Julien ; Castellsague, Xavier ; Curado, Maria Paula ; Maso, Luigino Dal ; Daudt, Alexander W. ; Fabianova, Eleonora ; Fernandez, Leticia ; Wünsch-Filho, Victor ; Franceschi, Silvia ; Hayes, Richard B. ; Herrero, Rolando ; Koifman, Sergio ; Lazarus, Philip ; Lence, Juan J. ; Levi, Fabio ; Mates, Dana ; Matos, Elena ; Menezes, Ana ; Muscat, Joshua ; Eluf-Neto, Jose ; Olshan, Andrew F. ; Rudnai, Peter ; Shangina, Oxana ; Sturgis, Erich M. ; Szeszenia-Dabrowska, Neonilia ; Talamini, Renato ; Wei, Qingyi ; Winn, Deborah M. ; Zaridze, David ; Lissowska, Jolanta ; Zhang, Zuo Feng ; Ferro, Gilles ; Brennan, Paul ; Vecchia, Carlo La ; Hashibe, Mia. / Family history of cancer : Pooled analysis in the International Head and Neck Cancer Epidemiology consortium. In: International Journal of Cancer. 2009 ; Vol. 124, No. 2. pp. 394-401.
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abstract = "Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC OR = 1.7, 95{\%} confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR = 2.2, 95{\%} CI 1.6-3.1) rather than a parent (OR = 1.5, 95{\%} CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95{\%} CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR = 1.1, 95{\%} CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR = 1.3, 95{\%} CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR = 1.0, 95{\%} CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.",
author = "Eva Negri and Paolo Boffetta and Julien Berthiller and Xavier Castellsague and Curado, {Maria Paula} and Maso, {Luigino Dal} and Daudt, {Alexander W.} and Eleonora Fabianova and Leticia Fernandez and Victor W{\"u}nsch-Filho and Silvia Franceschi and Hayes, {Richard B.} and Rolando Herrero and Sergio Koifman and Philip Lazarus and Lence, {Juan J.} and Fabio Levi and Dana Mates and Elena Matos and Ana Menezes and Joshua Muscat and Jose Eluf-Neto and Olshan, {Andrew F.} and Peter Rudnai and Oxana Shangina and Sturgis, {Erich M.} and Neonilia Szeszenia-Dabrowska and Renato Talamini and Qingyi Wei and Winn, {Deborah M.} and David Zaridze and Jolanta Lissowska and Zhang, {Zuo Feng} and Gilles Ferro and Paul Brennan and Vecchia, {Carlo La} and Mia Hashibe",
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Negri, E, Boffetta, P, Berthiller, J, Castellsague, X, Curado, MP, Maso, LD, Daudt, AW, Fabianova, E, Fernandez, L, Wünsch-Filho, V, Franceschi, S, Hayes, RB, Herrero, R, Koifman, S, Lazarus, P, Lence, JJ, Levi, F, Mates, D, Matos, E, Menezes, A, Muscat, J, Eluf-Neto, J, Olshan, AF, Rudnai, P, Shangina, O, Sturgis, EM, Szeszenia-Dabrowska, N, Talamini, R, Wei, Q, Winn, DM, Zaridze, D, Lissowska, J, Zhang, ZF, Ferro, G, Brennan, P, Vecchia, CL & Hashibe, M 2009, 'Family history of cancer: Pooled analysis in the International Head and Neck Cancer Epidemiology consortium', International Journal of Cancer, vol. 124, no. 2, pp. 394-401. https://doi.org/10.1002/ijc.23848

Family history of cancer : Pooled analysis in the International Head and Neck Cancer Epidemiology consortium. / Negri, Eva; Boffetta, Paolo; Berthiller, Julien; Castellsague, Xavier; Curado, Maria Paula; Maso, Luigino Dal; Daudt, Alexander W.; Fabianova, Eleonora; Fernandez, Leticia; Wünsch-Filho, Victor; Franceschi, Silvia; Hayes, Richard B.; Herrero, Rolando; Koifman, Sergio; Lazarus, Philip; Lence, Juan J.; Levi, Fabio; Mates, Dana; Matos, Elena; Menezes, Ana; Muscat, Joshua; Eluf-Neto, Jose; Olshan, Andrew F.; Rudnai, Peter; Shangina, Oxana; Sturgis, Erich M.; Szeszenia-Dabrowska, Neonilia; Talamini, Renato; Wei, Qingyi; Winn, Deborah M.; Zaridze, David; Lissowska, Jolanta; Zhang, Zuo Feng; Ferro, Gilles; Brennan, Paul; Vecchia, Carlo La; Hashibe, Mia.

In: International Journal of Cancer, Vol. 124, No. 2, 15.01.2009, p. 394-401.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Family history of cancer

T2 - Pooled analysis in the International Head and Neck Cancer Epidemiology consortium

AU - Negri, Eva

AU - Boffetta, Paolo

AU - Berthiller, Julien

AU - Castellsague, Xavier

AU - Curado, Maria Paula

AU - Maso, Luigino Dal

AU - Daudt, Alexander W.

AU - Fabianova, Eleonora

AU - Fernandez, Leticia

AU - Wünsch-Filho, Victor

AU - Franceschi, Silvia

AU - Hayes, Richard B.

AU - Herrero, Rolando

AU - Koifman, Sergio

AU - Lazarus, Philip

AU - Lence, Juan J.

AU - Levi, Fabio

AU - Mates, Dana

AU - Matos, Elena

AU - Menezes, Ana

AU - Muscat, Joshua

AU - Eluf-Neto, Jose

AU - Olshan, Andrew F.

AU - Rudnai, Peter

AU - Shangina, Oxana

AU - Sturgis, Erich M.

AU - Szeszenia-Dabrowska, Neonilia

AU - Talamini, Renato

AU - Wei, Qingyi

AU - Winn, Deborah M.

AU - Zaridze, David

AU - Lissowska, Jolanta

AU - Zhang, Zuo Feng

AU - Ferro, Gilles

AU - Brennan, Paul

AU - Vecchia, Carlo La

AU - Hashibe, Mia

PY - 2009/1/15

Y1 - 2009/1/15

N2 - Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC OR = 1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR = 2.2, 95% CI 1.6-3.1) rather than a parent (OR = 1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR = 1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR = 1.3, 95% CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR = 1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.

AB - Alcohol and tobacco consumption are well-recognized risk factors for head and neck cancer (HNC). Evidence suggests that genetic predisposition may also play a role. Only a few epidemiologic studies, however, have considered the relation between HNC risk and family history of HNC and other cancers. We pooled individual-level data across 12 case-control studies including 8,967 HNC cases and 13,627 controls. We obtained pooled odds ratios (OR) using fixed and random effect models and adjusting for potential confounding factors. All statistical tests were two-sided. A family history of HNC in first-degree relatives increased the risk of HNC OR = 1.7, 95% confidence interval, CI, 1.2-2.3). The risk was higher when the affected relative was a sibling (OR = 2.2, 95% CI 1.6-3.1) rather than a parent (OR = 1.5, 95% CI 1.1-1.8) and for more distal HNC anatomic sites (hypopharynx and larynx). The risk was also higher, or limited to, in subjects exposed to tobacco. The OR rose to 7.2 (95% CI 5.5-9.5) among subjects with family history, who were alcohol and tobacco users. A weak but significant association (OR = 1.1, 95% CI 1.0-1.2) emerged for family history of other tobacco-related neoplasms, particularly with laryngeal cancer (OR = 1.3, 95% CI 1.1-1.5). No association was observed for family history of nontobacco-related neoplasms and the risk of HNC (OR = 1.0, 95% CI 0.9-1.1). Familial factors play a role in the etiology of HNC. In both subjects with and without family history of HNC, avoidance of tobacco and alcohol exposure may be the best way to avoid HNC.

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