FANCD2 Hurdles the DNA Interstrand Crosslink

George-Lucian Moldovan, Alan D. D'Andrea

Research output: Contribution to journalShort survey

14 Citations (Scopus)

Abstract

Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.

Original languageEnglish (US)
Pages (from-to)1222-1224
Number of pages3
JournalCell
Volume139
Issue number7
DOIs
StatePublished - Dec 24 2009

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Fanconi Anemia Complementation Group Proteins
DNA Replication
DNA
Enzymes
Repair

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Cite this

Moldovan, George-Lucian ; D'Andrea, Alan D. / FANCD2 Hurdles the DNA Interstrand Crosslink. In: Cell. 2009 ; Vol. 139, No. 7. pp. 1222-1224.
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FANCD2 Hurdles the DNA Interstrand Crosslink. / Moldovan, George-Lucian; D'Andrea, Alan D.

In: Cell, Vol. 139, No. 7, 24.12.2009, p. 1222-1224.

Research output: Contribution to journalShort survey

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