FANCD2 Hurdles the DNA Interstrand Crosslink

George Lucian Moldovan, Alan D. D'Andrea

Research output: Contribution to journalShort surveypeer-review

14 Scopus citations

Abstract

Left unrepaired, DNA interstrand crosslinks represent impassable hurdles for DNA replication, and their removal is a complicated stepwise process involving a variety of enzymes. In a recent paper in Science, Knipscheer et al. (2009) demonstrate that the Fanconi Anemia protein FANCD2 promotes multiple steps of the crosslink repair process.

Original languageEnglish (US)
Pages (from-to)1222-1224
Number of pages3
JournalCell
Volume139
Issue number7
DOIs
StatePublished - Dec 24 2009

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

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