Fatal malignant metastastic epithelioid angiomyolipoma presenting in a young woman: Case report and review of the literature

Edward Wyluda, Giselle Baquero, Nicholas Lamparella, Catherine Abendroth, Joseph Drabick

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Epithelioid angiomyolipomas (EAMLs) are rare mesenchymal tumors whose malignant variant is extremely uncommon and highly aggressive. Treatment strategies include chemo radiation, transcatheter arterial embol - ization and surgical resection, which has remained the mainstay treatment. Targeted therapies including mammalian target of rapamycin (mTOR) inhibitors such as Temsirolimus may offer some hope for progressive malignant EAMLs that are not amenable to other treatment modalities. We report a fatal case in a young female who presented with rapidly progressive metastatic EAML that did not respond to mTOR therapy. The literature has shown reduction in tumor burden with the use of mTOR inhibitors, but unfortunately due to the rarity of malignant EAML, a meaningful approach to treatment remains challenging. Copyright E. Wyluda et al., 2013.

Original languageEnglish (US)
Article numbere46
Pages (from-to)154-156
Number of pages3
JournalRare Tumors
Volume5
Issue number3
DOIs
StatePublished - Sep 26 2013

All Science Journal Classification (ASJC) codes

  • Histology
  • Oncology

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