FcγRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity

Ziaur S.M. Rahman, Boris Alabyev, Tim Manser

Research output: Contribution to journalArticle

25 Citations (Scopus)

Abstract

The low-affinity FcR for IgG FcγRIIB suppresses the development of IgG antoantibodies and autoimmune disease in normal individuals, but how this effect is mediated is incompletely understood. To investigate this issue, we created FcγRIIB-deficient versions of two previously described targeted BCR-transgenic lines of mice that contain follicular B cells with specificity for the hapten arsonate, but with different levels of antinuclear autoantigen reactivity. The primary development and tolerance of both types of B cells were unaltered by the absence of FcγRIIB. Moreover, the reduced p-azophenylarsonate-driven germinal center and memory responses characteristic of the highly autoreactive clonotype were not reversed by an intrinsic FcγRIIB deficiency. In contrast, the p-azophenylarsonate-driven primary Ab-forming cell responses of both clonotypes were equivalently increased by such a deficiency. In total, our data do not support the idea that FcγRIIB directly participates in the action of primary or germinal center tolerance checkpoints. In contrast, this receptor apparently contributes to the prevention of autoimmunity by suppressing the production of autoreactive IgGs from B cells that have breached tolerance checkpoints and entered the Ab-forming cell pathway due to spontaneous, or cross-reactive, Ag-mediated activation.

Original languageEnglish (US)
Pages (from-to)897-907
Number of pages11
JournalJournal of Immunology
Volume178
Issue number2
StatePublished - Jan 15 2007

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Germinal Center
p-Azobenzenearsonate
B-Lymphocytes
Antibodies
Immunoglobulin G
Haptens
Autoantigens
Autoimmunity
Transgenic Mice
Autoimmune Diseases

All Science Journal Classification (ASJC) codes

  • Immunology and Allergy
  • Immunology

Cite this

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FcγRIIB regulates autoreactive primary antibody-forming cell, but not germinal center B cell, activity. / Rahman, Ziaur S.M.; Alabyev, Boris; Manser, Tim.

In: Journal of Immunology, Vol. 178, No. 2, 15.01.2007, p. 897-907.

Research output: Contribution to journalArticle

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