Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation

Yuefeng Sun, Jianwei Sun, Panida Lungchukiet, Waise Quarni, Shengyu Yang, Xiaohong Zhang, Wenlong Bai

Research output: Contribution to journalArticle

12 Scopus citations

Abstract

Fe65 is a brain-enriched adaptor protein known for its role in the action of the Aβ amyloid precursor protein in neuronal cells and Alzheimer's disease, but little is known about its functions in cancer cells. The present study documents for the first time a role of Fe65 in suppressing breast cancer cell migration and invasion. Mechanistic studies suggest that the suppression is mediated through its phosphotyrosine binding domain 1 that mediates the recruitment of Tip60 to cortactin to stimulate its acetylation. The studies identify the Tip60 acetyltransferase as a cytoplasmic drug target for the therapeutic intervention of metastatic breast cancers.

Original languageEnglish (US)
Article number11529
JournalScientific reports
Volume5
DOIs
StatePublished - Jul 13 2015

All Science Journal Classification (ASJC) codes

  • General

Fingerprint Dive into the research topics of 'Fe65 Suppresses Breast Cancer Cell Migration and Invasion through Tip60 Mediated Cortactin Acetylation'. Together they form a unique fingerprint.

  • Cite this