Feature-based design of bio-degradable micro-patterned structures

Ibrahim T. Ozbolat, Michelle Marchany, Joseph A. Gardella, Frank V. Bright, Alex N. Cartwright, Robert Hard, Wesley L. Hicks, Bahattin Koc

Research output: Contribution to journalArticle

19 Citations (Scopus)

Abstract

This paper presents a novelfeature-based variational modeling to control the bio-degradation process and thus material release kinetics of biodegradable micro-structures. Pattern architecture of micro-structure is varied according to the predetermined degradation profile over the micro-structure based on tissue engineering requirements. Optimum pattern architecture is generated over the micro-structure with varying geometric features and degradation kinetics.Several micro-pattern examples are provided with different patterning features (PFs) and degradation profiles, and their time baseddegradation profilesarecalculated based on the developed biodegradation model. An experimental study of degradation process is also developed to compare a fabricated micro-structured biodegradable material to the developed computational model.

Original languageEnglish (US)
Pages (from-to)661-671
Number of pages11
JournalComputer-Aided Design and Applications
Volume6
Issue number5
DOIs
StatePublished - Dec 1 2009

Fingerprint

Feature-based Design
Microstructure
Degradation
Biodegradation
Kinetics
Tissue Engineering
Patterning
Tissue engineering
Computational Model
Experimental Study
Requirements
Modeling

All Science Journal Classification (ASJC) codes

  • Computational Mechanics
  • Computer Graphics and Computer-Aided Design
  • Computational Mathematics

Cite this

Ozbolat, I. T., Marchany, M., Gardella, J. A., Bright, F. V., Cartwright, A. N., Hard, R., ... Koc, B. (2009). Feature-based design of bio-degradable micro-patterned structures. Computer-Aided Design and Applications, 6(5), 661-671. https://doi.org/10.3722/cadaps.2009.661-671
Ozbolat, Ibrahim T. ; Marchany, Michelle ; Gardella, Joseph A. ; Bright, Frank V. ; Cartwright, Alex N. ; Hard, Robert ; Hicks, Wesley L. ; Koc, Bahattin. / Feature-based design of bio-degradable micro-patterned structures. In: Computer-Aided Design and Applications. 2009 ; Vol. 6, No. 5. pp. 661-671.
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Ozbolat, IT, Marchany, M, Gardella, JA, Bright, FV, Cartwright, AN, Hard, R, Hicks, WL & Koc, B 2009, 'Feature-based design of bio-degradable micro-patterned structures', Computer-Aided Design and Applications, vol. 6, no. 5, pp. 661-671. https://doi.org/10.3722/cadaps.2009.661-671

Feature-based design of bio-degradable micro-patterned structures. / Ozbolat, Ibrahim T.; Marchany, Michelle; Gardella, Joseph A.; Bright, Frank V.; Cartwright, Alex N.; Hard, Robert; Hicks, Wesley L.; Koc, Bahattin.

In: Computer-Aided Design and Applications, Vol. 6, No. 5, 01.12.2009, p. 661-671.

Research output: Contribution to journalArticle

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