FeLV-FAIDS-induced immunodeficiency syndrome in cats

James I. Mullins, Edward A. Hoover, Julie Overbaugh, Sandra L. Quackenbush, Peter R. Donahue, Mary L. Poss

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Findings are reviewed, relevant to elucidation of the pathogenic, genetic and biochemical properties of a single, genetically heterogeneous isolate of feline leukemia virus (FeLV-FAIDS) shown to induce fatal immunodeficiency disease in nearly 100% of inoculated cats. Hypotheses are suggested which pertain to the mechanism of T-cell killing by this virus, and which extrapolate findings in the FeLV-FAIDS animal model to AIDS induced in humans by human immunodeficiency virus (HIV).

Original languageEnglish (US)
Pages (from-to)25-37
Number of pages13
JournalVeterinary Immunology and Immunopathology
Issue number1
StatePublished - May 1989

All Science Journal Classification (ASJC) codes

  • Immunology
  • veterinary(all)

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    Mullins, J. I., Hoover, E. A., Overbaugh, J., Quackenbush, S. L., Donahue, P. R., & Poss, M. L. (1989). FeLV-FAIDS-induced immunodeficiency syndrome in cats. Veterinary Immunology and Immunopathology, 21(1), 25-37. https://doi.org/10.1016/0165-2427(89)90127-X