FEM Optimization of Energy Density in Tumor Hyperthermia Using Time-Dependent Magnetic Nanoparticle Power Dissipation

Caleb Maxwel Koch, Leigh Winfrey

Research output: Contribution to journalArticle

1 Citation (Scopus)

Abstract

General principles are developed using a finite element model regarding how time-dependent power dissipation of magnetic nanoparticles can be used to optimize hyperthermia selectivity. To make the simulation more realistic, the finite size and spatial location of each individual nanoparticle is taken into consideration. When energy input into the system and duration of treatment is held constant, increasing the maximum power dissipation of nanoparticles increases concentrations of energy in the tumor. Furthermore, when the power dissipation of magnetic nanoparticles rises linearly, the temperature gradient on the edge of the tumor increases exponentially. With energy input held constant, the location and duration of maximum power dissipation in the treatment time scheme will affect the final energy concentration inside the tumor. Finally, connections are made between the simulation results and optimization of the design of nanoparticle power dissipation time-schemes for hyperthermia.

Original languageEnglish (US)
Article number6835180
JournalIEEE Transactions on Magnetics
Volume50
Issue number10
DOIs
StatePublished - Oct 1 2014

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Tumors
Energy dissipation
Nanoparticles
Finite element method
Thermal gradients

All Science Journal Classification (ASJC) codes

  • Electronic, Optical and Magnetic Materials
  • Electrical and Electronic Engineering

Cite this

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abstract = "General principles are developed using a finite element model regarding how time-dependent power dissipation of magnetic nanoparticles can be used to optimize hyperthermia selectivity. To make the simulation more realistic, the finite size and spatial location of each individual nanoparticle is taken into consideration. When energy input into the system and duration of treatment is held constant, increasing the maximum power dissipation of nanoparticles increases concentrations of energy in the tumor. Furthermore, when the power dissipation of magnetic nanoparticles rises linearly, the temperature gradient on the edge of the tumor increases exponentially. With energy input held constant, the location and duration of maximum power dissipation in the treatment time scheme will affect the final energy concentration inside the tumor. Finally, connections are made between the simulation results and optimization of the design of nanoparticle power dissipation time-schemes for hyperthermia.",
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FEM Optimization of Energy Density in Tumor Hyperthermia Using Time-Dependent Magnetic Nanoparticle Power Dissipation. / Koch, Caleb Maxwel; Winfrey, Leigh.

In: IEEE Transactions on Magnetics, Vol. 50, No. 10, 6835180, 01.10.2014.

Research output: Contribution to journalArticle

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