Femoral vascular occlusion and ventilation during recovery from heavy exercise

Philippe Haouzi, A. Huszczuk, J. Porszasz, B. Chalon, K. Wasserman, B. J. Whipp

Research output: Contribution to journalArticlepeer-review

35 Scopus citations

Abstract

Ventilation and cardiac output subside gradually following cessation of exercise, which is commonly linked to the slow wash-out of materials from the recovering muscles. The effect of hindering the removal of the metabolic products of heavy cycle exercise on the kinetics of ventilation and gas exchange was studied in 5 subjects by occluding the femoral circulation with cuffs during the first 2 min of recovery (15 tests). Fifteen undisturbed recoveries served as controls. Compared to spontaneous recovery, circulatory obstruction induced an immediated (from the first breath) decrease in minute ventilation (V̇E), while end-tidal CO2 (PetCO2) as well as lactate and K+ in venous blood at forearm did not change significantly. A ventilatory deficit of 27±9 L was observed from the 2 min of occlusion. Following cuff deflation, V̇E rose 2-3 breaths after PetCO2 began to increase in every subject. The mechanisms of the normocapnic reduction of V̇E during occlusion, as well as the rise of ventilation following cuff release, are still unclear. However, these results argue against any significant role for hyperpnea-inducing intramuscular chemoreception, or point to muscular perfusion as a prerequisite of such a mechanism to operate.

Original languageEnglish (US)
Pages (from-to)137-150
Number of pages14
JournalRespiration Physiology
Volume94
Issue number2
DOIs
StatePublished - Nov 1993

All Science Journal Classification (ASJC) codes

  • Physiology
  • Pulmonary and Respiratory Medicine

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