Ferrofluid-Based Droplet Interface Bilayer Networks

Michelle Makhoul-Mansour, Wujun Zhao, Nicole Gay, Colleen O'Connor, Joseph Najem, Leidong Mao, Eric C. Freeman

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

Droplet interface bilayer (DIB) networks allow for the construction of stimuli-responsive, membrane-based materials. Traditionally used for studying cellular transport phenomena, the DIB technique has proven its practicality when creating structured droplet networks. These structures consist of aqueous compartments capable of exchanging their contents across membranous barriers in a regulated fashion via embedded biomolecules, thus approximating the activity of natural cellular systems. However, lipid bilayer networks are often static and incapable of any reconfiguration in their architecture. In this study, we investigate the incorporation of a magnetic fluid or ferrofluid within the droplet phases for the creation of magnetically responsive DIB arrays. The impact of adding ferrofluid to the aqueous phases of the DIB networks is assessed by examining the bilayers' interfacial tensions, thickness, and channel activity. Once compatibility is established, potential applications of the ferrofluid-enabled DIBs are showcased by remotely modifying membrane qualities through magnetic fields. Ferrofluids do not significantly alter the bilayers' properties or functionality and can therefore be safely embedded within the DIB platform, allowing for remote manipulation of the interfacial bilayer properties.

Original languageEnglish (US)
Pages (from-to)13000-13007
Number of pages8
JournalLangmuir
Volume33
Issue number45
DOIs
StatePublished - Nov 14 2017

Fingerprint

Magnetic fluids
ferrofluids
diffuse interstellar bands
membranes
exchanging
compartments
Membranes
stimuli
compatibility
lipids
Lipid bilayers
manipulators
interfacial tension
platforms
Biomolecules
Surface tension
fluids
Magnetic fields
magnetic fields

All Science Journal Classification (ASJC) codes

  • Materials Science(all)
  • Condensed Matter Physics
  • Surfaces and Interfaces
  • Spectroscopy
  • Electrochemistry

Cite this

Makhoul-Mansour, M., Zhao, W., Gay, N., O'Connor, C., Najem, J., Mao, L., & Freeman, E. C. (2017). Ferrofluid-Based Droplet Interface Bilayer Networks. Langmuir, 33(45), 13000-13007. https://doi.org/10.1021/acs.langmuir.7b03055
Makhoul-Mansour, Michelle ; Zhao, Wujun ; Gay, Nicole ; O'Connor, Colleen ; Najem, Joseph ; Mao, Leidong ; Freeman, Eric C. / Ferrofluid-Based Droplet Interface Bilayer Networks. In: Langmuir. 2017 ; Vol. 33, No. 45. pp. 13000-13007.
@article{2045de5d43634d2e9dadb5c5b7a3c3e5,
title = "Ferrofluid-Based Droplet Interface Bilayer Networks",
abstract = "Droplet interface bilayer (DIB) networks allow for the construction of stimuli-responsive, membrane-based materials. Traditionally used for studying cellular transport phenomena, the DIB technique has proven its practicality when creating structured droplet networks. These structures consist of aqueous compartments capable of exchanging their contents across membranous barriers in a regulated fashion via embedded biomolecules, thus approximating the activity of natural cellular systems. However, lipid bilayer networks are often static and incapable of any reconfiguration in their architecture. In this study, we investigate the incorporation of a magnetic fluid or ferrofluid within the droplet phases for the creation of magnetically responsive DIB arrays. The impact of adding ferrofluid to the aqueous phases of the DIB networks is assessed by examining the bilayers' interfacial tensions, thickness, and channel activity. Once compatibility is established, potential applications of the ferrofluid-enabled DIBs are showcased by remotely modifying membrane qualities through magnetic fields. Ferrofluids do not significantly alter the bilayers' properties or functionality and can therefore be safely embedded within the DIB platform, allowing for remote manipulation of the interfacial bilayer properties.",
author = "Michelle Makhoul-Mansour and Wujun Zhao and Nicole Gay and Colleen O'Connor and Joseph Najem and Leidong Mao and Freeman, {Eric C.}",
year = "2017",
month = "11",
day = "14",
doi = "10.1021/acs.langmuir.7b03055",
language = "English (US)",
volume = "33",
pages = "13000--13007",
journal = "Langmuir",
issn = "0743-7463",
publisher = "American Chemical Society",
number = "45",

}

Makhoul-Mansour, M, Zhao, W, Gay, N, O'Connor, C, Najem, J, Mao, L & Freeman, EC 2017, 'Ferrofluid-Based Droplet Interface Bilayer Networks', Langmuir, vol. 33, no. 45, pp. 13000-13007. https://doi.org/10.1021/acs.langmuir.7b03055

Ferrofluid-Based Droplet Interface Bilayer Networks. / Makhoul-Mansour, Michelle; Zhao, Wujun; Gay, Nicole; O'Connor, Colleen; Najem, Joseph; Mao, Leidong; Freeman, Eric C.

In: Langmuir, Vol. 33, No. 45, 14.11.2017, p. 13000-13007.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Ferrofluid-Based Droplet Interface Bilayer Networks

AU - Makhoul-Mansour, Michelle

AU - Zhao, Wujun

AU - Gay, Nicole

AU - O'Connor, Colleen

AU - Najem, Joseph

AU - Mao, Leidong

AU - Freeman, Eric C.

PY - 2017/11/14

Y1 - 2017/11/14

N2 - Droplet interface bilayer (DIB) networks allow for the construction of stimuli-responsive, membrane-based materials. Traditionally used for studying cellular transport phenomena, the DIB technique has proven its practicality when creating structured droplet networks. These structures consist of aqueous compartments capable of exchanging their contents across membranous barriers in a regulated fashion via embedded biomolecules, thus approximating the activity of natural cellular systems. However, lipid bilayer networks are often static and incapable of any reconfiguration in their architecture. In this study, we investigate the incorporation of a magnetic fluid or ferrofluid within the droplet phases for the creation of magnetically responsive DIB arrays. The impact of adding ferrofluid to the aqueous phases of the DIB networks is assessed by examining the bilayers' interfacial tensions, thickness, and channel activity. Once compatibility is established, potential applications of the ferrofluid-enabled DIBs are showcased by remotely modifying membrane qualities through magnetic fields. Ferrofluids do not significantly alter the bilayers' properties or functionality and can therefore be safely embedded within the DIB platform, allowing for remote manipulation of the interfacial bilayer properties.

AB - Droplet interface bilayer (DIB) networks allow for the construction of stimuli-responsive, membrane-based materials. Traditionally used for studying cellular transport phenomena, the DIB technique has proven its practicality when creating structured droplet networks. These structures consist of aqueous compartments capable of exchanging their contents across membranous barriers in a regulated fashion via embedded biomolecules, thus approximating the activity of natural cellular systems. However, lipid bilayer networks are often static and incapable of any reconfiguration in their architecture. In this study, we investigate the incorporation of a magnetic fluid or ferrofluid within the droplet phases for the creation of magnetically responsive DIB arrays. The impact of adding ferrofluid to the aqueous phases of the DIB networks is assessed by examining the bilayers' interfacial tensions, thickness, and channel activity. Once compatibility is established, potential applications of the ferrofluid-enabled DIBs are showcased by remotely modifying membrane qualities through magnetic fields. Ferrofluids do not significantly alter the bilayers' properties or functionality and can therefore be safely embedded within the DIB platform, allowing for remote manipulation of the interfacial bilayer properties.

UR - http://www.scopus.com/inward/record.url?scp=85034058396&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=85034058396&partnerID=8YFLogxK

U2 - 10.1021/acs.langmuir.7b03055

DO - 10.1021/acs.langmuir.7b03055

M3 - Article

AN - SCOPUS:85034058396

VL - 33

SP - 13000

EP - 13007

JO - Langmuir

JF - Langmuir

SN - 0743-7463

IS - 45

ER -

Makhoul-Mansour M, Zhao W, Gay N, O'Connor C, Najem J, Mao L et al. Ferrofluid-Based Droplet Interface Bilayer Networks. Langmuir. 2017 Nov 14;33(45):13000-13007. https://doi.org/10.1021/acs.langmuir.7b03055