TY - JOUR
T1 - Fertility drugs and cancer
T2 - a guideline
AU - Pfeifer, Samantha
AU - Butts, Samantha
AU - Dumesic, Daniel
AU - Fossum, Gregory
AU - Gracia, Clarisa
AU - La Barbera, Andrew
AU - Mersereau, Jennifer
AU - Odem, Randall
AU - Paulson, Richard
AU - Penzias, Alan
AU - Pisarska, Margareta
AU - Rebar, Robert
AU - Reindollar, Richard
AU - Rosen, Mitchell
AU - Sandlow, Jay
AU - Vernon, Michael
AU - Widra, Eric
N1 - Publisher Copyright:
© 2016
PY - 2016/12/1
Y1 - 2016/12/1
N2 - Methodological limitations in studying the association between the use of fertility drugs and cancer include the inherent increased risk of cancer in women who never conceive, the low incidence of most of these cancers, and that the age of diagnosis of cancer typically is many years after fertility drug use. Based on available data, there does not appear to be a meaningful increased risk of invasive ovarian cancer, breast cancer, or endometrial cancer following the use of fertility drugs. Several studies have shown a small increased risk of borderline ovarian tumors; however, there is insufficient consistent evidence that a particular fertility drug increases the risk of borderline ovarian tumors, and any absolute risk is small. Given the available literature, patients should be counseled that infertile women may be at an increased risk of invasive ovarian, endometrial, and breast cancer; however, use of fertility drugs does not appear to increase this risk.
AB - Methodological limitations in studying the association between the use of fertility drugs and cancer include the inherent increased risk of cancer in women who never conceive, the low incidence of most of these cancers, and that the age of diagnosis of cancer typically is many years after fertility drug use. Based on available data, there does not appear to be a meaningful increased risk of invasive ovarian cancer, breast cancer, or endometrial cancer following the use of fertility drugs. Several studies have shown a small increased risk of borderline ovarian tumors; however, there is insufficient consistent evidence that a particular fertility drug increases the risk of borderline ovarian tumors, and any absolute risk is small. Given the available literature, patients should be counseled that infertile women may be at an increased risk of invasive ovarian, endometrial, and breast cancer; however, use of fertility drugs does not appear to increase this risk.
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U2 - 10.1016/j.fertnstert.2016.08.035
DO - 10.1016/j.fertnstert.2016.08.035
M3 - Article
C2 - 27573989
AN - SCOPUS:84995814797
VL - 106
SP - 1617
EP - 1626
JO - Fertility and Sterility
JF - Fertility and Sterility
SN - 0015-0282
IS - 7
ER -