Abstract
The fibrosis and scar formation that characterize adult wound healing are also the cause of clinical problems; scar contracture, hypertrophic scar, and pulmonary and hepatic fibrosis are only a few examples. Studies of fetal wound healing can provide an insight into the initiation and regulation of a scarless repair process akin to regeneration. Studies of fetal repair have already suggested mechanisms that might favorably alter adult healing. Topical application of hyaluronic acid to wounds in adult diabetic rats leads to enhanced epithelial migration. It has been recognized that the addition of TGF-β to fetal wounds causes an adultlike healing response with fibrosis and inflammation. A subsequent study using neutralizing antibody to TGF-β in adult wounds showed enhanced healing with a more normal dermal architecture with fewer macrophages, fewer blood vessels, and less collagen. As our understanding of regenerative tissue repair increases, the opportunities to modulate adult fibrotic conditions should expand.
| Original language | English (US) |
|---|---|
| Pages (from-to) | 677-683 |
| Number of pages | 7 |
| Journal | Dermatologic Clinics |
| Volume | 11 |
| Issue number | 4 |
| State | Published - Jan 1 1993 |
Fingerprint
All Science Journal Classification (ASJC) codes
- Dermatology
Cite this
}
Fetal tissue repair and wound healing. / Bleacher, J. C.; Adolph, V. R.; Dillon, P. W.; Krummel, T. M.
In: Dermatologic Clinics, Vol. 11, No. 4, 01.01.1993, p. 677-683.Research output: Contribution to journal › Review article
TY - JOUR
T1 - Fetal tissue repair and wound healing
AU - Bleacher, J. C.
AU - Adolph, V. R.
AU - Dillon, P. W.
AU - Krummel, T. M.
PY - 1993/1/1
Y1 - 1993/1/1
N2 - The fibrosis and scar formation that characterize adult wound healing are also the cause of clinical problems; scar contracture, hypertrophic scar, and pulmonary and hepatic fibrosis are only a few examples. Studies of fetal wound healing can provide an insight into the initiation and regulation of a scarless repair process akin to regeneration. Studies of fetal repair have already suggested mechanisms that might favorably alter adult healing. Topical application of hyaluronic acid to wounds in adult diabetic rats leads to enhanced epithelial migration. It has been recognized that the addition of TGF-β to fetal wounds causes an adultlike healing response with fibrosis and inflammation. A subsequent study using neutralizing antibody to TGF-β in adult wounds showed enhanced healing with a more normal dermal architecture with fewer macrophages, fewer blood vessels, and less collagen. As our understanding of regenerative tissue repair increases, the opportunities to modulate adult fibrotic conditions should expand.
AB - The fibrosis and scar formation that characterize adult wound healing are also the cause of clinical problems; scar contracture, hypertrophic scar, and pulmonary and hepatic fibrosis are only a few examples. Studies of fetal wound healing can provide an insight into the initiation and regulation of a scarless repair process akin to regeneration. Studies of fetal repair have already suggested mechanisms that might favorably alter adult healing. Topical application of hyaluronic acid to wounds in adult diabetic rats leads to enhanced epithelial migration. It has been recognized that the addition of TGF-β to fetal wounds causes an adultlike healing response with fibrosis and inflammation. A subsequent study using neutralizing antibody to TGF-β in adult wounds showed enhanced healing with a more normal dermal architecture with fewer macrophages, fewer blood vessels, and less collagen. As our understanding of regenerative tissue repair increases, the opportunities to modulate adult fibrotic conditions should expand.
UR - http://www.scopus.com/inward/record.url?scp=0027429415&partnerID=8YFLogxK
UR - http://www.scopus.com/inward/citedby.url?scp=0027429415&partnerID=8YFLogxK
M3 - Review article
C2 - 8222351
AN - SCOPUS:0027429415
VL - 11
SP - 677
EP - 683
JO - Dermatologic Clinics
JF - Dermatologic Clinics
SN - 0733-8635
IS - 4
ER -