Fibrinolytic response to acute exercise in patients with peripheral arterial disease

C. J. Womack, F. M. Ivey, A. W. Gardner, R. F. Macko

Research output: Contribution to journalArticle

27 Citations (Scopus)

Abstract

Purpose: Elevations in tissue plasminogen activator (tPA) are postulated to protect against atherothrombotic events during exercise. However, fibrinolytic response to repetitive bouts of symptom-limited exercise is unknown in peripheral arterial disease (PAD) patients, a population with impaired fibrinolysis and increased risk for ischemic events. The purpose of the present study was to evaluate the fibrinolytic response to repetitive bouts of symptom-limited exercise in PAD patients. Methods: Nine (8 male, 1 female) patients with Fontaine State II PAD were studied. Fasting blood samples for determination of tPA and plasminogen activator inhibitor (PAI-1) were obtained into an acidified citrate solution via an indwelling venous catheter before, immediately after, 30 min after, and 60 min after submaximal treadmill walking. Patients walked intermittently at 65% of maximal intensity achieved on a previous graded exercise test until 30 min of exercise was achieved. Results: Exercise increased tPA activity by 180% (0.5 ± 0.16 IU·mL-1 baseline, 1.4 ± 1.2 IU·mL-1 postexercise), and decreased PAI-1 activity by 40% (20.6 ± 5.5 AU·mL-1 baseline, 11.8 ± 6.2 AU·mL-1 postexercise), without changing tPA or PAI-1 antigen. Notably, plasma tPA activity levels 1 h after exercise remained elevated by 80%, whereas PAI-1 activity remained decreased by 49%. The decrease in PAI-1 significantly (P < 0.05) correlated with oxygen uptake (VO2) during submaximal exercise (r = -0.77). Conclusion: These findings demonstrate that repetitive bouts of symptom-limited exercise produce a substantial improvement in the fibrinolytic profile of PAD patients, which persists at least 1 h after exercise cessation.

Original languageEnglish (US)
Pages (from-to)214-219
Number of pages6
JournalMedicine and science in sports and exercise
Volume33
Issue number2
DOIs
StatePublished - Jan 1 2001

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Peripheral Arterial Disease
Plasminogen Activator Inhibitor 1
Exercise
Tissue Plasminogen Activator
Indwelling Catheters
Fibrinolysis
Exercise Test
Citric Acid
Walking
Fasting
Oxygen
Antigens

All Science Journal Classification (ASJC) codes

  • Orthopedics and Sports Medicine
  • Physical Therapy, Sports Therapy and Rehabilitation

Cite this

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title = "Fibrinolytic response to acute exercise in patients with peripheral arterial disease",
abstract = "Purpose: Elevations in tissue plasminogen activator (tPA) are postulated to protect against atherothrombotic events during exercise. However, fibrinolytic response to repetitive bouts of symptom-limited exercise is unknown in peripheral arterial disease (PAD) patients, a population with impaired fibrinolysis and increased risk for ischemic events. The purpose of the present study was to evaluate the fibrinolytic response to repetitive bouts of symptom-limited exercise in PAD patients. Methods: Nine (8 male, 1 female) patients with Fontaine State II PAD were studied. Fasting blood samples for determination of tPA and plasminogen activator inhibitor (PAI-1) were obtained into an acidified citrate solution via an indwelling venous catheter before, immediately after, 30 min after, and 60 min after submaximal treadmill walking. Patients walked intermittently at 65{\%} of maximal intensity achieved on a previous graded exercise test until 30 min of exercise was achieved. Results: Exercise increased tPA activity by 180{\%} (0.5 ± 0.16 IU·mL-1 baseline, 1.4 ± 1.2 IU·mL-1 postexercise), and decreased PAI-1 activity by 40{\%} (20.6 ± 5.5 AU·mL-1 baseline, 11.8 ± 6.2 AU·mL-1 postexercise), without changing tPA or PAI-1 antigen. Notably, plasma tPA activity levels 1 h after exercise remained elevated by 80{\%}, whereas PAI-1 activity remained decreased by 49{\%}. The decrease in PAI-1 significantly (P < 0.05) correlated with oxygen uptake (VO2) during submaximal exercise (r = -0.77). Conclusion: These findings demonstrate that repetitive bouts of symptom-limited exercise produce a substantial improvement in the fibrinolytic profile of PAD patients, which persists at least 1 h after exercise cessation.",
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Fibrinolytic response to acute exercise in patients with peripheral arterial disease. / Womack, C. J.; Ivey, F. M.; Gardner, A. W.; Macko, R. F.

In: Medicine and science in sports and exercise, Vol. 33, No. 2, 01.01.2001, p. 214-219.

Research output: Contribution to journalArticle

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T1 - Fibrinolytic response to acute exercise in patients with peripheral arterial disease

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AU - Ivey, F. M.

AU - Gardner, A. W.

AU - Macko, R. F.

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