Fibroblast adhesion on unidirectional polymeric nanofilms

Christof Christophis, Koray Sekeroglu, Gokhan Demirel, Isabel Thome, Michael Grunze, Melik C. Demirel, Axel Rosenhahn

Research output: Contribution to journalArticlepeer-review

9 Scopus citations

Abstract

Nanotextured polymeric surfaces with inclined rods reveal highly anisotropic properties concerning wetting and adhesion. In this work, we report on the interaction of fibroblast cells with these highly anisotropic materials. The authors quantified removal of adherent cells from such surfaces by a laminar flow. The critical shear force needed for cell removal from the surface depends on the inclination direction. Based on electron microscopy cross sections we deduce that interactions of cellular filopodia extending into the nanotextured surface are causing the direction depending removal.

Original languageEnglish (US)
Pages (from-to)158-163
Number of pages6
JournalBiointerphases
Volume6
Issue number4
DOIs
StatePublished - Dec 2011

All Science Journal Classification (ASJC) codes

  • Chemistry(all)
  • Biomaterials
  • Materials Science(all)
  • Biochemistry, Genetics and Molecular Biology(all)
  • Physics and Astronomy(all)

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