Fighting microbial pathogens by integrating host ecosystem interactions and evolution

Alita R. Burmeister, Elsa Hansen, Jessica J. Cunningham, E. Hesper Rego, Paul E. Turner, Joshua S. Weitz, Michael E. Hochberg

Research output: Contribution to journalArticlepeer-review

Abstract

Successful therapies to combat microbial diseases and cancers require incorporating ecological and evolutionary principles. Drawing upon the fields of ecology and evolutionary biology, we present a systems-based approach in which host and disease-causing factors are considered as part of a complex network of interactions, analogous to studies of “classical” ecosystems. Centering this approach around empirical examples of disease treatment, we present evidence that successful therapies invariably engage multiple interactions with other components of the host ecosystem. Many of these factors interact nonlinearly to yield synergistic benefits and curative outcomes. We argue that these synergies and nonlinear feedbacks must be leveraged to improve the study of pathogenesis in situ and to develop more effective therapies. An eco-evolutionary systems perspective has surprising and important consequences, and we use it to articulate areas of high research priority for improving treatment strategies.

Original languageEnglish (US)
JournalBioEssays
DOIs
StateAccepted/In press - 2020

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)

Fingerprint Dive into the research topics of 'Fighting microbial pathogens by integrating host ecosystem interactions and evolution'. Together they form a unique fingerprint.

Cite this