Figuration and detection of single molecules

R. Nevels, G. R. Welch, P. S. Cremer, P. Hemmer, T. Phillips, S. Scully, A. V. Sokolov, A. A. Svidzinsky, H. Xia, A. Zheltikov, M. O. Scully

Research output: Contribution to journalArticlepeer-review

5 Scopus citations

Abstract

Recent advances in the description of atoms and molecules based on Dimensional scaling analysis, developed by Dudley Herschbach and co-workers, provided new insights into visualization of molecular structure and chemical bonding. Prof. Herschbach is also a giant in the field of single molecule scattering. We here report on the engineering of molecular detectors. Such systems have a wide range of application from medical diagnostics to the monitoring of chemical, biological and environmental hazards. We discuss ways to identify preselected molecules, in particular, mycotoxin contaminants using coherent laser spectroscopy. Mycotoxin contaminants, e.g. aflatoxin B1 which is present in corn and peanuts, are usually analysed by time-consuming microscopic, chemical and biological assays. We present a new approach that derives from recent experiments in which molecules are prepared by one (or more) femtosecond laser(s) and probed by another set. We call this technique FAST CARS (femto second adaptive spectroscopic technique for coherent anti-Stokes Raman spectroscopy). We propose and analyse ways in which FAST CARS can be used to identify preselected molecules, e.g. aflatoxin, rapidly and economically.

Original languageEnglish (US)
Pages (from-to)1993-2000
Number of pages8
JournalMolecular Physics
Volume110
Issue number15-16
DOIs
StatePublished - Aug 10 2012

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Molecular Biology
  • Condensed Matter Physics
  • Physical and Theoretical Chemistry

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