Final report of the amended safety assessment of quaternium-15 as used in cosmetics

Lillian C. Becker, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, Ronald Hill, Daniel Leibler, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticlepeer-review

6 Scopus citations

Abstract

Quaternium-15 is an antimicrobial agent used in cosmetics as a cosmetic preservative and antistatic agent. Little systemic toxicity was reported in most single-dose or repeated-dose animal studies. Quaternium-15 was an oral teratogen, but not a dermal teratogen, in rats at doses that exceeded the expected cumulative exposure from cosmetics. The frequency of sensitization increased in North America but not in Europe, where Quaternium-15 is used less often. In almost all animal and human studies, Quaternium-15 at 0.2% was not a sensitizer. The weight of evidence suggested that a 0.2% concentration is not a sensitizer and that cosmetic products containing Quaternium-15 up to that level are safe.

Original languageEnglish (US)
Pages (from-to)98S-114S
JournalInternational journal of toxicology
Volume29
Issue number3_suppl
DOIs
StatePublished - Jan 1 2010

All Science Journal Classification (ASJC) codes

  • Toxicology

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