Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols

Valerie C. Robinson, Wilma F. Bergfeld, Donald V. Belsito, Ronald A. Hill, Curtis D. Klaassen, James G. Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalArticle

24 Citations (Scopus)

Abstract

Sodium laureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics. Sodium and ammonium laureth sulfate have not evoked adverse responses in any toxicological testing. Sodium laureth sulfate was demonstrated to be a dermal and ocular irritant but not a sensitizer. The Expert Panel recognized that there are data gaps regarding use and concentration of these ingredients. However, the overall information available on the types of products in which these ingredients are used and at what concentrations indicates a pattern of use. The potential to produce irritation exists with these salts of sulfated ethoxylated alcohols, but in practice they are not regularly seen to be irritating because of the formulations in which they are used. These ingredients should be used only when they can be formulated to be nonirritating.

Original languageEnglish (US)
Pages (from-to)151S-161S
JournalInternational journal of toxicology
Volume29
Issue number4
DOIs
StatePublished - Sep 9 2010

Fingerprint

Cosmetics
Salts
Alcohols
Safety
Irritants
Ammonium Compounds
Sulfates
Sodium
Ammonium Sulfate
Toxicology
Testing
Skin
sodium laureth sulfate
polidocanol

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Robinson, Valerie C. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Hill, Ronald A. ; Klaassen, Curtis D. ; Marks, James G. ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Andersen, F. Alan. / Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols. In: International journal of toxicology. 2010 ; Vol. 29, No. 4. pp. 151S-161S.
@article{cbc0dc6dd71f4d7aab51417ceef0bf3a,
title = "Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols",
abstract = "Sodium laureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics. Sodium and ammonium laureth sulfate have not evoked adverse responses in any toxicological testing. Sodium laureth sulfate was demonstrated to be a dermal and ocular irritant but not a sensitizer. The Expert Panel recognized that there are data gaps regarding use and concentration of these ingredients. However, the overall information available on the types of products in which these ingredients are used and at what concentrations indicates a pattern of use. The potential to produce irritation exists with these salts of sulfated ethoxylated alcohols, but in practice they are not regularly seen to be irritating because of the formulations in which they are used. These ingredients should be used only when they can be formulated to be nonirritating.",
author = "Robinson, {Valerie C.} and Bergfeld, {Wilma F.} and Belsito, {Donald V.} and Hill, {Ronald A.} and Klaassen, {Curtis D.} and Marks, {James G.} and Shank, {Ronald C.} and Slaga, {Thomas J.} and Snyder, {Paul W.} and Andersen, {F. Alan}",
year = "2010",
month = "9",
day = "9",
doi = "10.1177/1091581810373151",
language = "English (US)",
volume = "29",
pages = "151S--161S",
journal = "International Journal of Toxicology",
issn = "1091-5818",
publisher = "SAGE Publications Inc.",
number = "4",

}

Robinson, VC, Bergfeld, WF, Belsito, DV, Hill, RA, Klaassen, CD, Marks, JG, Shank, RC, Slaga, TJ, Snyder, PW & Andersen, FA 2010, 'Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols', International journal of toxicology, vol. 29, no. 4, pp. 151S-161S. https://doi.org/10.1177/1091581810373151

Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols. / Robinson, Valerie C.; Bergfeld, Wilma F.; Belsito, Donald V.; Hill, Ronald A.; Klaassen, Curtis D.; Marks, James G.; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Andersen, F. Alan.

In: International journal of toxicology, Vol. 29, No. 4, 09.09.2010, p. 151S-161S.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Final report of the amended safety assessment of sodium laureth sulfate and related salts of sulfated ethoxylated alcohols

AU - Robinson, Valerie C.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Hill, Ronald A.

AU - Klaassen, Curtis D.

AU - Marks, James G.

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Andersen, F. Alan

PY - 2010/9/9

Y1 - 2010/9/9

N2 - Sodium laureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics. Sodium and ammonium laureth sulfate have not evoked adverse responses in any toxicological testing. Sodium laureth sulfate was demonstrated to be a dermal and ocular irritant but not a sensitizer. The Expert Panel recognized that there are data gaps regarding use and concentration of these ingredients. However, the overall information available on the types of products in which these ingredients are used and at what concentrations indicates a pattern of use. The potential to produce irritation exists with these salts of sulfated ethoxylated alcohols, but in practice they are not regularly seen to be irritating because of the formulations in which they are used. These ingredients should be used only when they can be formulated to be nonirritating.

AB - Sodium laureth sulfate is a member of a group of salts of sulfated ethoxylated alcohols, the safety of which was evaluated by the Cosmetic Ingredient Review (CIR) Expert Panel for use in cosmetics. Sodium and ammonium laureth sulfate have not evoked adverse responses in any toxicological testing. Sodium laureth sulfate was demonstrated to be a dermal and ocular irritant but not a sensitizer. The Expert Panel recognized that there are data gaps regarding use and concentration of these ingredients. However, the overall information available on the types of products in which these ingredients are used and at what concentrations indicates a pattern of use. The potential to produce irritation exists with these salts of sulfated ethoxylated alcohols, but in practice they are not regularly seen to be irritating because of the formulations in which they are used. These ingredients should be used only when they can be formulated to be nonirritating.

UR - http://www.scopus.com/inward/record.url?scp=77956288645&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=77956288645&partnerID=8YFLogxK

U2 - 10.1177/1091581810373151

DO - 10.1177/1091581810373151

M3 - Article

C2 - 20634505

AN - SCOPUS:77956288645

VL - 29

SP - 151S-161S

JO - International Journal of Toxicology

JF - International Journal of Toxicology

SN - 1091-5818

IS - 4

ER -