Final report on the safety assessment of amino nitrophenols as used in hair dyes.

Christina L. Burnett, Wilma F. Bergfeld, Donald V. Belsito, Curtis D. Klaassen, James Marks, Ronald C. Shank, Thomas J. Slaga, Paul W. Snyder, F. Alan Andersen

Research output: Contribution to journalReview article

3 Citations (Scopus)

Abstract

2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 4-amino-2-nitrophenol, 2-amino-4-nitrophenol sulfate, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are substituted aromatic compounds used as semipermanent (nonoxidative) hair colorants and as toners in permanent (oxidative) hair dye products. All ingredients in this group except 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, and 4-amino-2-nitrophenol have reported uses in cosmetics at use concentrations from 2% to 9%. The available toxicity studies for these amino nitrophenol hair dyes did not suggest safety concerns except for the potential carcinogenicity and mutagenicity of 4-amino-2-nitrophenol. 2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a safety determination for 4-amino-2-nitrophenol.

Original languageEnglish (US)
JournalInternational Journal of Toxicology
Volume28
Issue number6 Suppl 2
DOIs
StatePublished - Jan 1 2009

Fingerprint

Hair Dyes
Nitrophenols
Safety
Sulfates
Cosmetics
Aromatic compounds
Toxicity
3-nitrophenol
2-amino-4-nitrophenol
4-amino-2-nitrophenol

All Science Journal Classification (ASJC) codes

  • Toxicology

Cite this

Burnett, C. L., Bergfeld, W. F., Belsito, D. V., Klaassen, C. D., Marks, J., Shank, R. C., ... Alan Andersen, F. (2009). Final report on the safety assessment of amino nitrophenols as used in hair dyes. International Journal of Toxicology, 28(6 Suppl 2). https://doi.org/10.1177/1091581809354651
Burnett, Christina L. ; Bergfeld, Wilma F. ; Belsito, Donald V. ; Klaassen, Curtis D. ; Marks, James ; Shank, Ronald C. ; Slaga, Thomas J. ; Snyder, Paul W. ; Alan Andersen, F. / Final report on the safety assessment of amino nitrophenols as used in hair dyes. In: International Journal of Toxicology. 2009 ; Vol. 28, No. 6 Suppl 2.
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title = "Final report on the safety assessment of amino nitrophenols as used in hair dyes.",
abstract = "2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 4-amino-2-nitrophenol, 2-amino-4-nitrophenol sulfate, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are substituted aromatic compounds used as semipermanent (nonoxidative) hair colorants and as toners in permanent (oxidative) hair dye products. All ingredients in this group except 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, and 4-amino-2-nitrophenol have reported uses in cosmetics at use concentrations from 2{\%} to 9{\%}. The available toxicity studies for these amino nitrophenol hair dyes did not suggest safety concerns except for the potential carcinogenicity and mutagenicity of 4-amino-2-nitrophenol. 2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a safety determination for 4-amino-2-nitrophenol.",
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Burnett, CL, Bergfeld, WF, Belsito, DV, Klaassen, CD, Marks, J, Shank, RC, Slaga, TJ, Snyder, PW & Alan Andersen, F 2009, 'Final report on the safety assessment of amino nitrophenols as used in hair dyes.', International Journal of Toxicology, vol. 28, no. 6 Suppl 2. https://doi.org/10.1177/1091581809354651

Final report on the safety assessment of amino nitrophenols as used in hair dyes. / Burnett, Christina L.; Bergfeld, Wilma F.; Belsito, Donald V.; Klaassen, Curtis D.; Marks, James; Shank, Ronald C.; Slaga, Thomas J.; Snyder, Paul W.; Alan Andersen, F.

In: International Journal of Toxicology, Vol. 28, No. 6 Suppl 2, 01.01.2009.

Research output: Contribution to journalReview article

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T1 - Final report on the safety assessment of amino nitrophenols as used in hair dyes.

AU - Burnett, Christina L.

AU - Bergfeld, Wilma F.

AU - Belsito, Donald V.

AU - Klaassen, Curtis D.

AU - Marks, James

AU - Shank, Ronald C.

AU - Slaga, Thomas J.

AU - Snyder, Paul W.

AU - Alan Andersen, F.

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N2 - 2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 4-amino-2-nitrophenol, 2-amino-4-nitrophenol sulfate, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are substituted aromatic compounds used as semipermanent (nonoxidative) hair colorants and as toners in permanent (oxidative) hair dye products. All ingredients in this group except 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, and 4-amino-2-nitrophenol have reported uses in cosmetics at use concentrations from 2% to 9%. The available toxicity studies for these amino nitrophenol hair dyes did not suggest safety concerns except for the potential carcinogenicity and mutagenicity of 4-amino-2-nitrophenol. 2-Amino-3-nitrophenol, 2-amino-4-nitrophenol, 2-amino-4-nitrophenol sulfate, 2-amino-5-nitrophenol, 4-amino-3-nitrophenol, 3-nitro-p-hydroxyethylaminophenol, and 4-hydroxypropylamino-3-nitrophenol are safe as hair dye ingredients in the practices of use and concentration as described in this safety assessment, but the data are insufficient to make a safety determination for 4-amino-2-nitrophenol.

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