Finasteride in the treatment of men with frontal male pattern hair loss

J. Leyden, F. Dunlap, B. Miller, P. Winters, M. Lebwohl, D. Hecker, S. Kraus, H. Baldwin, A. Shalita, Z. Draelos, M. Markou, D. Thiboutot, M. Rapaport, S. Kang, T. Kelly, D. Pariser, G. Webster, M. Hordinsky, R. Rietschel, H. I. KatzL. Terranella, S. Best, E. Round, J. Waldstreicher

Research output: Contribution to journalArticle

146 Citations (Scopus)

Abstract

Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double- blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.

Original languageEnglish (US)
Pages (from-to)930-937
Number of pages8
JournalJournal of the American Academy of Dermatology
Volume40
Issue number6 I
DOIs
StatePublished - Jan 1 1999

Fingerprint

Finasteride
Alopecia
Scalp
Hair
Research Personnel
Therapeutics
Dihydrotestosterone
Oxidoreductases
Placebos
Growth
Serum

All Science Journal Classification (ASJC) codes

  • Dermatology

Cite this

Leyden, J., Dunlap, F., Miller, B., Winters, P., Lebwohl, M., Hecker, D., ... Waldstreicher, J. (1999). Finasteride in the treatment of men with frontal male pattern hair loss. Journal of the American Academy of Dermatology, 40(6 I), 930-937. https://doi.org/10.1016/S0190-9622(99)70081-2
Leyden, J. ; Dunlap, F. ; Miller, B. ; Winters, P. ; Lebwohl, M. ; Hecker, D. ; Kraus, S. ; Baldwin, H. ; Shalita, A. ; Draelos, Z. ; Markou, M. ; Thiboutot, D. ; Rapaport, M. ; Kang, S. ; Kelly, T. ; Pariser, D. ; Webster, G. ; Hordinsky, M. ; Rietschel, R. ; Katz, H. I. ; Terranella, L. ; Best, S. ; Round, E. ; Waldstreicher, J. / Finasteride in the treatment of men with frontal male pattern hair loss. In: Journal of the American Academy of Dermatology. 1999 ; Vol. 40, No. 6 I. pp. 930-937.
@article{7a12a2318b5d4c7d9ae17bd07efa5c4b,
title = "Finasteride in the treatment of men with frontal male pattern hair loss",
abstract = "Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double- blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.",
author = "J. Leyden and F. Dunlap and B. Miller and P. Winters and M. Lebwohl and D. Hecker and S. Kraus and H. Baldwin and A. Shalita and Z. Draelos and M. Markou and D. Thiboutot and M. Rapaport and S. Kang and T. Kelly and D. Pariser and G. Webster and M. Hordinsky and R. Rietschel and Katz, {H. I.} and L. Terranella and S. Best and E. Round and J. Waldstreicher",
year = "1999",
month = "1",
day = "1",
doi = "10.1016/S0190-9622(99)70081-2",
language = "English (US)",
volume = "40",
pages = "930--937",
journal = "Journal of the American Academy of Dermatology",
issn = "0190-9622",
publisher = "Mosby Inc.",
number = "6 I",

}

Leyden, J, Dunlap, F, Miller, B, Winters, P, Lebwohl, M, Hecker, D, Kraus, S, Baldwin, H, Shalita, A, Draelos, Z, Markou, M, Thiboutot, D, Rapaport, M, Kang, S, Kelly, T, Pariser, D, Webster, G, Hordinsky, M, Rietschel, R, Katz, HI, Terranella, L, Best, S, Round, E & Waldstreicher, J 1999, 'Finasteride in the treatment of men with frontal male pattern hair loss', Journal of the American Academy of Dermatology, vol. 40, no. 6 I, pp. 930-937. https://doi.org/10.1016/S0190-9622(99)70081-2

Finasteride in the treatment of men with frontal male pattern hair loss. / Leyden, J.; Dunlap, F.; Miller, B.; Winters, P.; Lebwohl, M.; Hecker, D.; Kraus, S.; Baldwin, H.; Shalita, A.; Draelos, Z.; Markou, M.; Thiboutot, D.; Rapaport, M.; Kang, S.; Kelly, T.; Pariser, D.; Webster, G.; Hordinsky, M.; Rietschel, R.; Katz, H. I.; Terranella, L.; Best, S.; Round, E.; Waldstreicher, J.

In: Journal of the American Academy of Dermatology, Vol. 40, No. 6 I, 01.01.1999, p. 930-937.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Finasteride in the treatment of men with frontal male pattern hair loss

AU - Leyden, J.

AU - Dunlap, F.

AU - Miller, B.

AU - Winters, P.

AU - Lebwohl, M.

AU - Hecker, D.

AU - Kraus, S.

AU - Baldwin, H.

AU - Shalita, A.

AU - Draelos, Z.

AU - Markou, M.

AU - Thiboutot, D.

AU - Rapaport, M.

AU - Kang, S.

AU - Kelly, T.

AU - Pariser, D.

AU - Webster, G.

AU - Hordinsky, M.

AU - Rietschel, R.

AU - Katz, H. I.

AU - Terranella, L.

AU - Best, S.

AU - Round, E.

AU - Waldstreicher, J.

PY - 1999/1/1

Y1 - 1999/1/1

N2 - Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double- blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.

AB - Background: Finasteride, a specific inhibitor of type II 5α-reductase, decreases serum and scalp dihydrotestosterone and has been shown to be effective in men with vertex male pattern hair loss. Objective: This study evaluated the efficacy of finasteride 1 mg/day in men with frontal (anterior/mid) scalp hair thinning. Methods: This was a 1-year, double- blind, placebo-controlled study followed by a 1-year open extension. Efficacy was assessed by hair counts (1 cm2 circular area), patient and investigator assessments, and global photographic review. Results: There was a significant increase in hair count in the frontal scalp of finasteride-treated patients (P < .001), as well as significant improvements in patient, investigator, and global photographic assessments. Efficacy was maintained or improved throughout the second year of the study. Finasteride was generally well tolerated. Conclusion: In men with hair loss in the anterior/mid area of the scalp, finasteride 1 mg/day slowed hair loss and increased hair growth.

UR - http://www.scopus.com/inward/record.url?scp=0033067815&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=0033067815&partnerID=8YFLogxK

U2 - 10.1016/S0190-9622(99)70081-2

DO - 10.1016/S0190-9622(99)70081-2

M3 - Article

C2 - 10365924

AN - SCOPUS:0033067815

VL - 40

SP - 930

EP - 937

JO - Journal of the American Academy of Dermatology

JF - Journal of the American Academy of Dermatology

SN - 0190-9622

IS - 6 I

ER -