Finding partners to play the music of regulation

Research output: Contribution to journalReview article

Abstract

In this issue of Blood, Wilson et al generate and analyze a treasure trove of epigenetic data, such as transcription factor occupancy, histone modifications, and chromatin interaction frequencies, genome-wide (ie, epigenomic data), in a cell line model of hematopoietic stem/progenitor cells (HSPCs).1 To appreciate the importance of these data, consider an analogy of gene expression being a song or symphony (transcripts) played by musicians (transcription factors and transcriptional machinery) reading the score encoded in the genome sequence. Previous studies2 revealed the positions of a few transcription factors across the genome, so we only knew about, for example, the violinists and oboists. No wonder we did not understand how the music was being generated (how expression was regulated). By mapping the sites of occupancy of many more transcription factors (now a total of 29), as well as positions of 4 histone modifications and DNase hypersensitive sites, Wilson et al1 reveal many more of the players and their partners. Furthermore, their data on 3-dimensional interaction frequencies of chromatin show how groups of musicians (protein complexes) come together in an orchestra to read the score and perform a symphony.

Original languageEnglish (US)
Pages (from-to)1624-1626
Number of pages3
JournalBlood
Volume127
Issue number13
DOIs
StatePublished - Mar 31 2016

Fingerprint

Music
Transcription Factors
Histone Code
Genes
Genome
Hematopoietic Stem Cells
Epigenomics
Histones
Chromatin
Deoxyribonucleases
Stem cells
Gene expression
Machinery
Reading
Blood
Cells
Gene Expression
Cell Line
Proteins

All Science Journal Classification (ASJC) codes

  • Immunology
  • Biochemistry
  • Hematology
  • Cell Biology

Cite this

Hardison, Ross C. / Finding partners to play the music of regulation. In: Blood. 2016 ; Vol. 127, No. 13. pp. 1624-1626.
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Finding partners to play the music of regulation. / Hardison, Ross C.

In: Blood, Vol. 127, No. 13, 31.03.2016, p. 1624-1626.

Research output: Contribution to journalReview article

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AU - Hardison, Ross C.

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AB - In this issue of Blood, Wilson et al generate and analyze a treasure trove of epigenetic data, such as transcription factor occupancy, histone modifications, and chromatin interaction frequencies, genome-wide (ie, epigenomic data), in a cell line model of hematopoietic stem/progenitor cells (HSPCs).1 To appreciate the importance of these data, consider an analogy of gene expression being a song or symphony (transcripts) played by musicians (transcription factors and transcriptional machinery) reading the score encoded in the genome sequence. Previous studies2 revealed the positions of a few transcription factors across the genome, so we only knew about, for example, the violinists and oboists. No wonder we did not understand how the music was being generated (how expression was regulated). By mapping the sites of occupancy of many more transcription factors (now a total of 29), as well as positions of 4 histone modifications and DNase hypersensitive sites, Wilson et al1 reveal many more of the players and their partners. Furthermore, their data on 3-dimensional interaction frequencies of chromatin show how groups of musicians (protein complexes) come together in an orchestra to read the score and perform a symphony.

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