Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults

Gaurav S. Ajmani, Helen H. Suh, Kristen E. Wroblewski, David W. Kern, L. Philip Schumm, Martha K. McClintock, Jeffrey Yanosky, Jayant M. Pinto

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Objectives The olfactory nerve is anatomically susceptible to injury from pollution in inspired air, but there are no large-scale epidemiologic studies investigating this relationship. Methods Cross-sectional study using data from the National Social Life, Health, and Aging Project, a representative sample of home-dwelling US adults age 57–85 years. Olfactory function was tested using a validated 5-item odor identification test (Sniffin' Sticks). Exposure to fine particulate matter (PM2.5) at each respondent's home was estimated as 1–12 month moving averages prior to olfactory assessment using validated spatio-temporal models. Results Olfactory dysfunction was significantly associated with PM2.5 exposures averaged over 3–12 months in urban-dwelling respondents. The strongest effect was for 6 month average exposure (per 1-IQR increase in PM2.5: OR 1.28, 95% CI 1.05, 1.55) adjusting for age, gender, race/ethnicity, education, cognition, comorbidity, smoking, and the season. Interestingly, the most deleterious effects were observed among the youngest respondents, 57–64 years old, and those living in the northeast and south. Conclusions We show for the first time that air pollution exposure is associated with poor olfaction among urban-living, older US adults.

Original languageEnglish (US)
Pages (from-to)797-803
Number of pages7
JournalEnvironmental Research
Volume151
DOIs
StatePublished - Nov 1 2016

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Particulate Matter
Odors
Air pollution
particulate matter
Pollution
Aging of materials
Education
Health
Air
Olfactory Nerve
pollution exposure
olfaction
Smell
cognition
Air Pollution
ethnicity
smoking
Cognition
odor
Comorbidity

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Environmental Science(all)

Cite this

Ajmani, G. S., Suh, H. H., Wroblewski, K. E., Kern, D. W., Schumm, L. P., McClintock, M. K., ... Pinto, J. M. (2016). Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults. Environmental Research, 151, 797-803. https://doi.org/10.1016/j.envres.2016.09.012
Ajmani, Gaurav S. ; Suh, Helen H. ; Wroblewski, Kristen E. ; Kern, David W. ; Schumm, L. Philip ; McClintock, Martha K. ; Yanosky, Jeffrey ; Pinto, Jayant M. / Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults. In: Environmental Research. 2016 ; Vol. 151. pp. 797-803.
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Ajmani, GS, Suh, HH, Wroblewski, KE, Kern, DW, Schumm, LP, McClintock, MK, Yanosky, J & Pinto, JM 2016, 'Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults', Environmental Research, vol. 151, pp. 797-803. https://doi.org/10.1016/j.envres.2016.09.012

Fine particulate matter exposure and olfactory dysfunction among urban-dwelling older US adults. / Ajmani, Gaurav S.; Suh, Helen H.; Wroblewski, Kristen E.; Kern, David W.; Schumm, L. Philip; McClintock, Martha K.; Yanosky, Jeffrey; Pinto, Jayant M.

In: Environmental Research, Vol. 151, 01.11.2016, p. 797-803.

Research output: Contribution to journalArticle

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AU - Schumm, L. Philip

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AU - Yanosky, Jeffrey

AU - Pinto, Jayant M.

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N2 - Objectives The olfactory nerve is anatomically susceptible to injury from pollution in inspired air, but there are no large-scale epidemiologic studies investigating this relationship. Methods Cross-sectional study using data from the National Social Life, Health, and Aging Project, a representative sample of home-dwelling US adults age 57–85 years. Olfactory function was tested using a validated 5-item odor identification test (Sniffin' Sticks). Exposure to fine particulate matter (PM2.5) at each respondent's home was estimated as 1–12 month moving averages prior to olfactory assessment using validated spatio-temporal models. Results Olfactory dysfunction was significantly associated with PM2.5 exposures averaged over 3–12 months in urban-dwelling respondents. The strongest effect was for 6 month average exposure (per 1-IQR increase in PM2.5: OR 1.28, 95% CI 1.05, 1.55) adjusting for age, gender, race/ethnicity, education, cognition, comorbidity, smoking, and the season. Interestingly, the most deleterious effects were observed among the youngest respondents, 57–64 years old, and those living in the northeast and south. Conclusions We show for the first time that air pollution exposure is associated with poor olfaction among urban-living, older US adults.

AB - Objectives The olfactory nerve is anatomically susceptible to injury from pollution in inspired air, but there are no large-scale epidemiologic studies investigating this relationship. Methods Cross-sectional study using data from the National Social Life, Health, and Aging Project, a representative sample of home-dwelling US adults age 57–85 years. Olfactory function was tested using a validated 5-item odor identification test (Sniffin' Sticks). Exposure to fine particulate matter (PM2.5) at each respondent's home was estimated as 1–12 month moving averages prior to olfactory assessment using validated spatio-temporal models. Results Olfactory dysfunction was significantly associated with PM2.5 exposures averaged over 3–12 months in urban-dwelling respondents. The strongest effect was for 6 month average exposure (per 1-IQR increase in PM2.5: OR 1.28, 95% CI 1.05, 1.55) adjusting for age, gender, race/ethnicity, education, cognition, comorbidity, smoking, and the season. Interestingly, the most deleterious effects were observed among the youngest respondents, 57–64 years old, and those living in the northeast and south. Conclusions We show for the first time that air pollution exposure is associated with poor olfaction among urban-living, older US adults.

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