TY - JOUR
T1 - Finite element analysis of microelectrotension of cell membranes
AU - Bae, Chilman
AU - Butler, Peter J.
N1 - Funding Information:
Acknowledgments This work was supported in part by grants to P.J.B. from the National Heart Lung and Blood Institute (R01 HL 077542-01A1) and the National Science Foundation (CAREER Award BES 0238910).
PY - 2008/10
Y1 - 2008/10
N2 - Electric fields can be focused by micropipette-based electrodes to induce stresses on cell membranes leading to tension and poration. To date, however, these membrane stress distributions have not been quantified. In this study, we determine membrane tension, stress, and strain distributions in the vicinity of a microelectrode using finite element analysis of a multiscale electro-mechanical model of pipette, media, membrane, actin cortex, and cytoplasm. Electric field forces are coupled to membranes using the Maxwell stress tensor and membrane electrocompression theory. Results suggest that micropipette electrodes provide a new non-contact method to deliver physiological stresses directly to membranes in a focused and controlled manner, thus providing the quantitative foundation for micreoelectrotension, a new technique for membrane mechanobiology.
AB - Electric fields can be focused by micropipette-based electrodes to induce stresses on cell membranes leading to tension and poration. To date, however, these membrane stress distributions have not been quantified. In this study, we determine membrane tension, stress, and strain distributions in the vicinity of a microelectrode using finite element analysis of a multiscale electro-mechanical model of pipette, media, membrane, actin cortex, and cytoplasm. Electric field forces are coupled to membranes using the Maxwell stress tensor and membrane electrocompression theory. Results suggest that micropipette electrodes provide a new non-contact method to deliver physiological stresses directly to membranes in a focused and controlled manner, thus providing the quantitative foundation for micreoelectrotension, a new technique for membrane mechanobiology.
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U2 - 10.1007/s10237-007-0093-y
DO - 10.1007/s10237-007-0093-y
M3 - Article
C2 - 17657517
AN - SCOPUS:50149112676
SN - 1617-7959
VL - 7
SP - 379
EP - 386
JO - Biomechanics and Modeling in Mechanobiology
JF - Biomechanics and Modeling in Mechanobiology
IS - 5
ER -