Finite element modeling of the pulmonary autograft at systemic pressure before remodeling

Peter B. Matthews, Choon Sik Jhun, Stephanie Yaung, Ali N. Azadani, Julius M. Guccione, Liang Ge, Elaine E. Tseng

Research output: Contribution to journalArticle

4 Citations (Scopus)

Abstract

Background and aim of the study: Pulmonary autograft dilatation requiring reoperation is an Achilles' heel of the Ross procedure, as exposure to systemic pressure increases autograft wall stress, which may in turn lead to tissue remodeling and aneurysmal pathology. However, the magnitude of autograft wall stress with the Ross procedure is unknown. The study aim was to develop a realistic finite element (FE) model of the autograft, and to perform simulations at systemic pressure to determine wall stress distribution immediately after the Ross operation. Methods: The porcine pulmonary root geometry was generated from high-resolution microcomputed tomography (microCT) images to create a mesh composed of hexahedral elements. Previously defined constitutive equations were used to describe the regional material properties of the native porcine pulmonary root. The anterior and posterior pulmonary arteries, and each of the pulmonary sinuses, were best described by non-linear, anisotropic Fung strain energy functions, and input individually into the model. Autograft dilatation and wall stress distribution during pulmonary and systemic loading prior to remodeling were determined using explicit FE analysis in LS-DYNA. Results: The autograft was highly compliant in the low-strain region, and the majority of dilation occurred with <30 mmHg of pressurization. During pulmonic loading, a typical inflation/deflation was observed between systole and diastole, but the autograft remained almost completely dilated throughout the cardiac cycle at systemic pressure. Although the systolic blood pressure was 380% greater in the aortic than in the pulmonary position, the peak systolic diameter was increased by only 28%. The maximum principal wall stress increased approximately 10-fold during systole and 25-fold during diastole, and was greater in the sinus than the distal artery for all simulations. Conclusion: Under systemic loading conditions, the pulmonary autograft remained fully dilated and experienced large wall stresses concentrated in the sinus. The future correlation of this model with explanted autografts may lead to an improved understanding of tissue remodeling following the Ross procedure.

Original languageEnglish (US)
Pages (from-to)45-52
Number of pages8
JournalJournal of Heart Valve Disease
Volume20
Issue number1
StatePublished - Jan 1 2011

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Autografts
Pressure
Lung
Dilatation
Diastole
Systole
Swine
Blood Pressure
X-Ray Microtomography
Finite Element Analysis
Economic Inflation
Reoperation
Pulmonary Artery
Arteries
Pathology

All Science Journal Classification (ASJC) codes

  • Cardiology and Cardiovascular Medicine

Cite this

Matthews, P. B., Jhun, C. S., Yaung, S., Azadani, A. N., Guccione, J. M., Ge, L., & Tseng, E. E. (2011). Finite element modeling of the pulmonary autograft at systemic pressure before remodeling. Journal of Heart Valve Disease, 20(1), 45-52.
Matthews, Peter B. ; Jhun, Choon Sik ; Yaung, Stephanie ; Azadani, Ali N. ; Guccione, Julius M. ; Ge, Liang ; Tseng, Elaine E. / Finite element modeling of the pulmonary autograft at systemic pressure before remodeling. In: Journal of Heart Valve Disease. 2011 ; Vol. 20, No. 1. pp. 45-52.
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abstract = "Background and aim of the study: Pulmonary autograft dilatation requiring reoperation is an Achilles' heel of the Ross procedure, as exposure to systemic pressure increases autograft wall stress, which may in turn lead to tissue remodeling and aneurysmal pathology. However, the magnitude of autograft wall stress with the Ross procedure is unknown. The study aim was to develop a realistic finite element (FE) model of the autograft, and to perform simulations at systemic pressure to determine wall stress distribution immediately after the Ross operation. Methods: The porcine pulmonary root geometry was generated from high-resolution microcomputed tomography (microCT) images to create a mesh composed of hexahedral elements. Previously defined constitutive equations were used to describe the regional material properties of the native porcine pulmonary root. The anterior and posterior pulmonary arteries, and each of the pulmonary sinuses, were best described by non-linear, anisotropic Fung strain energy functions, and input individually into the model. Autograft dilatation and wall stress distribution during pulmonary and systemic loading prior to remodeling were determined using explicit FE analysis in LS-DYNA. Results: The autograft was highly compliant in the low-strain region, and the majority of dilation occurred with <30 mmHg of pressurization. During pulmonic loading, a typical inflation/deflation was observed between systole and diastole, but the autograft remained almost completely dilated throughout the cardiac cycle at systemic pressure. Although the systolic blood pressure was 380{\%} greater in the aortic than in the pulmonary position, the peak systolic diameter was increased by only 28{\%}. The maximum principal wall stress increased approximately 10-fold during systole and 25-fold during diastole, and was greater in the sinus than the distal artery for all simulations. Conclusion: Under systemic loading conditions, the pulmonary autograft remained fully dilated and experienced large wall stresses concentrated in the sinus. The future correlation of this model with explanted autografts may lead to an improved understanding of tissue remodeling following the Ross procedure.",
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Matthews, PB, Jhun, CS, Yaung, S, Azadani, AN, Guccione, JM, Ge, L & Tseng, EE 2011, 'Finite element modeling of the pulmonary autograft at systemic pressure before remodeling', Journal of Heart Valve Disease, vol. 20, no. 1, pp. 45-52.

Finite element modeling of the pulmonary autograft at systemic pressure before remodeling. / Matthews, Peter B.; Jhun, Choon Sik; Yaung, Stephanie; Azadani, Ali N.; Guccione, Julius M.; Ge, Liang; Tseng, Elaine E.

In: Journal of Heart Valve Disease, Vol. 20, No. 1, 01.01.2011, p. 45-52.

Research output: Contribution to journalArticle

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AU - Ge, Liang

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N2 - Background and aim of the study: Pulmonary autograft dilatation requiring reoperation is an Achilles' heel of the Ross procedure, as exposure to systemic pressure increases autograft wall stress, which may in turn lead to tissue remodeling and aneurysmal pathology. However, the magnitude of autograft wall stress with the Ross procedure is unknown. The study aim was to develop a realistic finite element (FE) model of the autograft, and to perform simulations at systemic pressure to determine wall stress distribution immediately after the Ross operation. Methods: The porcine pulmonary root geometry was generated from high-resolution microcomputed tomography (microCT) images to create a mesh composed of hexahedral elements. Previously defined constitutive equations were used to describe the regional material properties of the native porcine pulmonary root. The anterior and posterior pulmonary arteries, and each of the pulmonary sinuses, were best described by non-linear, anisotropic Fung strain energy functions, and input individually into the model. Autograft dilatation and wall stress distribution during pulmonary and systemic loading prior to remodeling were determined using explicit FE analysis in LS-DYNA. Results: The autograft was highly compliant in the low-strain region, and the majority of dilation occurred with <30 mmHg of pressurization. During pulmonic loading, a typical inflation/deflation was observed between systole and diastole, but the autograft remained almost completely dilated throughout the cardiac cycle at systemic pressure. Although the systolic blood pressure was 380% greater in the aortic than in the pulmonary position, the peak systolic diameter was increased by only 28%. The maximum principal wall stress increased approximately 10-fold during systole and 25-fold during diastole, and was greater in the sinus than the distal artery for all simulations. Conclusion: Under systemic loading conditions, the pulmonary autograft remained fully dilated and experienced large wall stresses concentrated in the sinus. The future correlation of this model with explanted autografts may lead to an improved understanding of tissue remodeling following the Ross procedure.

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Matthews PB, Jhun CS, Yaung S, Azadani AN, Guccione JM, Ge L et al. Finite element modeling of the pulmonary autograft at systemic pressure before remodeling. Journal of Heart Valve Disease. 2011 Jan 1;20(1):45-52.