First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring

Emmi I.T. Helle; Preston Biegley; Joshua W. Knowles; Joseph B. Leader; Sarah Pendergrass; Wei Yang; Gerald R. Reaven; Gary M. Shaw; Marylyn Ritchie; James R. Priest

doi:10.1016/j.jpeds.2017.10.046

First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring

Emmi I.T. Helle, Preston Biegley, Joshua W. Knowles, Joseph B. Leader, Sarah Pendergrass, Wei Yang, Gerald R. Reaven, Gary M. Shaw, Marylyn Ritchie, James R. Priest

Research output: Contribution to journal › Article › peer-review

14 Scopus citations

Abstract

In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.

Original language	English (US)
Pages (from-to)	275-278
Number of pages	4
Journal	Journal of Pediatrics
Volume	195
DOIs	https://doi.org/10.1016/j.jpeds.2017.10.046
State	Published - Apr 2018

All Science Journal Classification (ASJC) codes

Pediatrics, Perinatology, and Child Health

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Helle, Emmi I.T. ; Biegley, Preston ; Knowles, Joshua W. ; Leader, Joseph B. ; Pendergrass, Sarah ; Yang, Wei ; Reaven, Gerald R. ; Shaw, Gary M. ; Ritchie, Marylyn ; Priest, James R. / First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring. In: Journal of Pediatrics. 2018 ; Vol. 195. pp. 275-278.

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abstract = "In a retrospective study of 19 171 mother-child dyads, elevated random plasma glucose values during early pregnancy were directly correlated with increased risk for congenital heart disease in offspring. Plasma glucose levels proximal to the period of cardiac development may represent a modifiable risk factor for congenital heart disease in expectant mothers without diabetes.",

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First Trimester Plasma Glucose Values in Women without Diabetes are Associated with Risk for Congenital Heart Disease in Offspring. / Helle, Emmi I.T.; Biegley, Preston; Knowles, Joshua W.; Leader, Joseph B.; Pendergrass, Sarah; Yang, Wei; Reaven, Gerald R.; Shaw, Gary M.; Ritchie, Marylyn; Priest, James R.

In: Journal of Pediatrics, Vol. 195, 04.2018, p. 275-278.

Research output: Contribution to journal › Article › peer-review

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