Fish intake and serum levels of organochlorines among Japanese women

H. Tsukino, T. Hanaoka, H. Sasaki, H. Motoyama, M. Hiroshima, T. Tanaka, M. Kabuto, W. Turner, D. G. Patterson, L. Needham, S. Tsugane

Research output: Contribution to journalArticle

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Abstract

This study evaluates background serum levels of selected organochlorine compounds among Japanese women of reproductive age and investigates whether lifestyle factors, especially dietary factors, may be associated with these levels. A cross-sectional study was performed on 80 Japanese women, aged 26-43 years, who complained of infertility and were confirmed not to have endometriosis. The serum levels of total toxic equivalency (TEQ), 18 polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs), 4 coplanar polychlorinated biphenyls (cPCBs), 36 ortho-substituted polychlorinated biphenyls (PCBs), and 13 chlorinated pesticides or their metabolites were measured and data were collected on the women's age, residence, occupation, body mass index (BMI), smoking and alcohol habit and 6 dietary intakes (fish, meats, rice, vegetables, fruits and dairy products). The serum median level of total TEQ was 25.1 pg TEQ/g lipid, that of PCDDs/PCDFs/cPCBs was 11.5 pmol/g lipid, that of PCBs was 0.46 nmol/g lipid, and that of total pesticides was 1.32 nmol/g lipid. The serum levels of total TEQ, PCDDs/PCDFs/cPCBs, PCBs and pesticides were positively associated with age (P for trend = 0.003, 0.01, 0.005 and 0.01, respectively) and frequent fish consumption (P for trend = 0.002, 0.003, 0.0003 and 0.006, respectively). Other lifestyle factors were not associated with serum organochlorine levels. The present study suggests that Japanese women who consume fish frequently in their reproductive period tend to accumulate organochlorines in their bodies.

Original languageEnglish (US)
Pages (from-to)90-100
Number of pages11
JournalScience of the Total Environment
Volume359
Issue number1-3
DOIs
StatePublished - Apr 15 2006

Fingerprint

Polychlorinated Biphenyls
Polychlorinated biphenyls
organochlorine
Fish
serum
PCB
Poisons
Lipids
PCDF
fish
Pesticides
lipid
dioxin
pesticide
lifestyle
Dairy products
Chlorinated Hydrocarbons
infertility
Meats
Vegetables

All Science Journal Classification (ASJC) codes

  • Environmental Engineering
  • Environmental Chemistry
  • Waste Management and Disposal
  • Pollution

Cite this

Tsukino, H., Hanaoka, T., Sasaki, H., Motoyama, H., Hiroshima, M., Tanaka, T., ... Tsugane, S. (2006). Fish intake and serum levels of organochlorines among Japanese women. Science of the Total Environment, 359(1-3), 90-100. https://doi.org/10.1016/j.scitotenv.2005.04.014
Tsukino, H. ; Hanaoka, T. ; Sasaki, H. ; Motoyama, H. ; Hiroshima, M. ; Tanaka, T. ; Kabuto, M. ; Turner, W. ; Patterson, D. G. ; Needham, L. ; Tsugane, S. / Fish intake and serum levels of organochlorines among Japanese women. In: Science of the Total Environment. 2006 ; Vol. 359, No. 1-3. pp. 90-100.
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Tsukino, H, Hanaoka, T, Sasaki, H, Motoyama, H, Hiroshima, M, Tanaka, T, Kabuto, M, Turner, W, Patterson, DG, Needham, L & Tsugane, S 2006, 'Fish intake and serum levels of organochlorines among Japanese women', Science of the Total Environment, vol. 359, no. 1-3, pp. 90-100. https://doi.org/10.1016/j.scitotenv.2005.04.014

Fish intake and serum levels of organochlorines among Japanese women. / Tsukino, H.; Hanaoka, T.; Sasaki, H.; Motoyama, H.; Hiroshima, M.; Tanaka, T.; Kabuto, M.; Turner, W.; Patterson, D. G.; Needham, L.; Tsugane, S.

In: Science of the Total Environment, Vol. 359, No. 1-3, 15.04.2006, p. 90-100.

Research output: Contribution to journalArticle

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T1 - Fish intake and serum levels of organochlorines among Japanese women

AU - Tsukino, H.

AU - Hanaoka, T.

AU - Sasaki, H.

AU - Motoyama, H.

AU - Hiroshima, M.

AU - Tanaka, T.

AU - Kabuto, M.

AU - Turner, W.

AU - Patterson, D. G.

AU - Needham, L.

AU - Tsugane, S.

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N2 - This study evaluates background serum levels of selected organochlorine compounds among Japanese women of reproductive age and investigates whether lifestyle factors, especially dietary factors, may be associated with these levels. A cross-sectional study was performed on 80 Japanese women, aged 26-43 years, who complained of infertility and were confirmed not to have endometriosis. The serum levels of total toxic equivalency (TEQ), 18 polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs), 4 coplanar polychlorinated biphenyls (cPCBs), 36 ortho-substituted polychlorinated biphenyls (PCBs), and 13 chlorinated pesticides or their metabolites were measured and data were collected on the women's age, residence, occupation, body mass index (BMI), smoking and alcohol habit and 6 dietary intakes (fish, meats, rice, vegetables, fruits and dairy products). The serum median level of total TEQ was 25.1 pg TEQ/g lipid, that of PCDDs/PCDFs/cPCBs was 11.5 pmol/g lipid, that of PCBs was 0.46 nmol/g lipid, and that of total pesticides was 1.32 nmol/g lipid. The serum levels of total TEQ, PCDDs/PCDFs/cPCBs, PCBs and pesticides were positively associated with age (P for trend = 0.003, 0.01, 0.005 and 0.01, respectively) and frequent fish consumption (P for trend = 0.002, 0.003, 0.0003 and 0.006, respectively). Other lifestyle factors were not associated with serum organochlorine levels. The present study suggests that Japanese women who consume fish frequently in their reproductive period tend to accumulate organochlorines in their bodies.

AB - This study evaluates background serum levels of selected organochlorine compounds among Japanese women of reproductive age and investigates whether lifestyle factors, especially dietary factors, may be associated with these levels. A cross-sectional study was performed on 80 Japanese women, aged 26-43 years, who complained of infertility and were confirmed not to have endometriosis. The serum levels of total toxic equivalency (TEQ), 18 polychlorinated dibenzo-p-dioxins (PCDDs)/polychlorinated dibenzofurans (PCDFs), 4 coplanar polychlorinated biphenyls (cPCBs), 36 ortho-substituted polychlorinated biphenyls (PCBs), and 13 chlorinated pesticides or their metabolites were measured and data were collected on the women's age, residence, occupation, body mass index (BMI), smoking and alcohol habit and 6 dietary intakes (fish, meats, rice, vegetables, fruits and dairy products). The serum median level of total TEQ was 25.1 pg TEQ/g lipid, that of PCDDs/PCDFs/cPCBs was 11.5 pmol/g lipid, that of PCBs was 0.46 nmol/g lipid, and that of total pesticides was 1.32 nmol/g lipid. The serum levels of total TEQ, PCDDs/PCDFs/cPCBs, PCBs and pesticides were positively associated with age (P for trend = 0.003, 0.01, 0.005 and 0.01, respectively) and frequent fish consumption (P for trend = 0.002, 0.003, 0.0003 and 0.006, respectively). Other lifestyle factors were not associated with serum organochlorine levels. The present study suggests that Japanese women who consume fish frequently in their reproductive period tend to accumulate organochlorines in their bodies.

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Tsukino H, Hanaoka T, Sasaki H, Motoyama H, Hiroshima M, Tanaka T et al. Fish intake and serum levels of organochlorines among Japanese women. Science of the Total Environment. 2006 Apr 15;359(1-3):90-100. https://doi.org/10.1016/j.scitotenv.2005.04.014