Fix L, a haemoglobin that acts as an oxygen sensor: Signalling mechanism and structural basis of its homology with PAS domains

Max F. Perutz, Massimo Paoli, Arthur M. Lesk

Research output: Contribution to journalShort surveypeer-review

55 Scopus citations

Abstract

Fix L, which contains a haemoglobin domain homologous to the PAS family and a histidine kinase complex that regulates expression of nitrogenase trigger stereochemical changes in and around the haem that, together with steric effects, control the activity of the kinase. Homology with the PAS family is based on a common core of about 20 structurally equivalent sites from which polar residues are excluded.

Original languageEnglish (US)
Pages (from-to)R291-R297
JournalChemistry and Biology
Volume6
Issue number11
DOIs
StatePublished - Nov 1999

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

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