Fix L, a haemoglobin that acts as an oxygen sensor: Signalling mechanism and structural basis of its homology with PAS domains

Max F. Perutz, Massimo Paoli, Arthur M. Lesk

Research output: Contribution to journalShort survey

55 Citations (Scopus)

Abstract

Fix L, which contains a haemoglobin domain homologous to the PAS family and a histidine kinase complex that regulates expression of nitrogenase trigger stereochemical changes in and around the haem that, together with steric effects, control the activity of the kinase. Homology with the PAS family is based on a common core of about 20 structurally equivalent sites from which polar residues are excluded.

Original languageEnglish (US)
Pages (from-to)R291-R297
JournalChemistry and Biology
Volume6
Issue number11
DOIs
StatePublished - Nov 1999

Fingerprint

Nitrogenase
Oxygen sensors
Heme
Hemoglobins
Phosphotransferases
Oxygen
Histidine
Histidine Kinase

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Medicine
  • Molecular Biology
  • Pharmacology
  • Drug Discovery
  • Clinical Biochemistry

Cite this

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Fix L, a haemoglobin that acts as an oxygen sensor : Signalling mechanism and structural basis of its homology with PAS domains. / Perutz, Max F.; Paoli, Massimo; Lesk, Arthur M.

In: Chemistry and Biology, Vol. 6, No. 11, 11.1999, p. R291-R297.

Research output: Contribution to journalShort survey

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