Fixed dynamometry is more sensitive than vital capacity or ALS rating scale

Patricia L. Andres, Margaret Peggy Allred, Helen E. Stephens, Mary Proffitt Bunnell, Catherine Siener, Eric A. Macklin, Travis Haines, Robert A. English, Katherine A. Fetterman, Edward J. Kasarskis, Julaine Florence, Zachary Simmons, Merit E. Cudkowicz

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017.

Original languageEnglish (US)
Pages (from-to)710-715
Number of pages6
JournalMuscle and Nerve
Volume56
Issue number4
DOIs
StatePublished - Oct 1 2017

Fingerprint

Vital Capacity
Amyotrophic Lateral Sclerosis
Extremities
Sample Size
Longitudinal Studies
Leg
Arm
Outcome Assessment (Health Care)
Muscles

All Science Journal Classification (ASJC) codes

  • Physiology
  • Clinical Neurology
  • Cellular and Molecular Neuroscience
  • Physiology (medical)

Cite this

Andres, P. L., Allred, M. P., Stephens, H. E., Proffitt Bunnell, M., Siener, C., Macklin, E. A., ... Cudkowicz, M. E. (2017). Fixed dynamometry is more sensitive than vital capacity or ALS rating scale. Muscle and Nerve, 56(4), 710-715. https://doi.org/10.1002/mus.25586
Andres, Patricia L. ; Allred, Margaret Peggy ; Stephens, Helen E. ; Proffitt Bunnell, Mary ; Siener, Catherine ; Macklin, Eric A. ; Haines, Travis ; English, Robert A. ; Fetterman, Katherine A. ; Kasarskis, Edward J. ; Florence, Julaine ; Simmons, Zachary ; Cudkowicz, Merit E. / Fixed dynamometry is more sensitive than vital capacity or ALS rating scale. In: Muscle and Nerve. 2017 ; Vol. 56, No. 4. pp. 710-715.
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Andres, PL, Allred, MP, Stephens, HE, Proffitt Bunnell, M, Siener, C, Macklin, EA, Haines, T, English, RA, Fetterman, KA, Kasarskis, EJ, Florence, J, Simmons, Z & Cudkowicz, ME 2017, 'Fixed dynamometry is more sensitive than vital capacity or ALS rating scale', Muscle and Nerve, vol. 56, no. 4, pp. 710-715. https://doi.org/10.1002/mus.25586

Fixed dynamometry is more sensitive than vital capacity or ALS rating scale. / Andres, Patricia L.; Allred, Margaret Peggy; Stephens, Helen E.; Proffitt Bunnell, Mary; Siener, Catherine; Macklin, Eric A.; Haines, Travis; English, Robert A.; Fetterman, Katherine A.; Kasarskis, Edward J.; Florence, Julaine; Simmons, Zachary; Cudkowicz, Merit E.

In: Muscle and Nerve, Vol. 56, No. 4, 01.10.2017, p. 710-715.

Research output: Contribution to journalArticle

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AU - Allred, Margaret Peggy

AU - Stephens, Helen E.

AU - Proffitt Bunnell, Mary

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AU - Macklin, Eric A.

AU - Haines, Travis

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AU - Kasarskis, Edward J.

AU - Florence, Julaine

AU - Simmons, Zachary

AU - Cudkowicz, Merit E.

PY - 2017/10/1

Y1 - 2017/10/1

N2 - Introduction: Improved outcome measures are essential to efficiently screen the growing number of potential amyotrophic lateral sclerosis (ALS) therapies. Methods: This longitudinal study of 100 (70 male) participants with ALS compared Accurate Test of Limb Isometric Strength (ATLIS), using a fixed, wireless load cell, with ALS Functional Rating Scale-Revised (ALSFRS-R) and vital capacity (VC). Results: Participants enrolled at 5 U.S. sites. Data were analyzed from 66 participants with complete ATLIS, ALSFRS-R, and VC data over at least 3 visits. Change in ATLIS was less variable both within- and among-person than change in ALSFRS-R or VC. Additionally, participants who had normal ALSFRS-R arm and leg function averaged 12 to 32% below expected strength values measured by ATLIS. Conclusions: ATLIS was more sensitive to change than ALSFRS-R or VC and could decrease sample size requirements by approximately one-third. The ability of ATLIS to detect prefunctional change has potential value in early trials. Muscle Nerve 56: 710–715, 2017.

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Andres PL, Allred MP, Stephens HE, Proffitt Bunnell M, Siener C, Macklin EA et al. Fixed dynamometry is more sensitive than vital capacity or ALS rating scale. Muscle and Nerve. 2017 Oct 1;56(4):710-715. https://doi.org/10.1002/mus.25586