FLASH: A rapid method for prototyping paper-based microfluidic devices

Andres W. Martinez, Scott T. Phillips, Benjamin J. Wiley, Malancha Gupta, George M. Whitesides

Research output: Contribution to journalArticlepeer-review

523 Scopus citations

Abstract

This article describes FLASH (Fast Lithographic Activation of Sheets), a rapid method for laboratory prototyping of microfluidic devices in paper. Paper-based microfluidic devices are emerging as a new technology for applications in diagnostics for the developing world, where low cost and simplicity are essential. FLASH is based on photolithography, but requires only a UV lamp and a hotplate; no clean-room or special facilities are required (FLASH patterning can even be performed in sunlight if a UV lamp and hotplate are unavailable). The method provides channels in paper with dimensions as small as 200 μm in width and 70 μm in height; the height is defined by the thickness of the paper. Photomasks for patterning paper-based microfluidic devices can be printed using an ink-jet printer or photocopier, or drawn by hand using a waterproof black pen. FLASH provides a straightforward method for prototyping paper-based microfluidic devices in regions where the technological support for conventional photolithography is not available.

Original languageEnglish (US)
Pages (from-to)2146-2150
Number of pages5
JournalLab on a Chip
Volume8
Issue number12
DOIs
StatePublished - 2008

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Biochemistry
  • Chemistry(all)
  • Biomedical Engineering

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