Flexible biodegradable citrate-based polymeric step-index optical fiber

Dingying Shan, Chenji Zhang, Surge Kalaba, Nikhil Mehta, Gloria B. Kim, Zhiwen Liu, Jian Yang

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

Implanting fiber optical waveguides into tissue or organs for light delivery and collection is among the most effective ways to overcome the issue of tissue turbidity, a long-standing obstacle for biomedical optical technologies. Here, we report a citrate-based material platform with engineerable opto-mechano-biological properties and demonstrate a new type of biodegradable, biocompatible, and low-loss step-index optical fiber for organ-scale light delivery and collection. By leveraging the rich designability and processibility of citrate-based biodegradable polymers, two exemplary biodegradable elastomers with a fine refractive index difference and yet matched mechanical properties and biodegradation profiles were developed. Furthermore, we developed a two-step fabrication method to fabricate flexible and low-loss (0.4 db/cm) optical fibers, and performed systematic characterizations to study optical, spectroscopic, mechanical, and biodegradable properties. In addition, we demonstrated the proof of concept of image transmission through the citrate-based polymeric optical fibers and conducted in vivo deep tissue light delivery and fluorescence sensing in a Sprague-Dawley (SD) rat, laying the groundwork for realizing future implantable devices for long-term implantation where deep-tissue light delivery, sensing and imaging are desired, such as cell, tissue, and scaffold imaging in regenerative medicine and in vivo optogenetic stimulation.

Original languageEnglish (US)
Pages (from-to)142-148
Number of pages7
JournalBiomaterials
Volume143
DOIs
StatePublished - Oct 1 2017

Fingerprint

Optical Fibers
Citric Acid
Optical fibers
Tissue
Light
Optogenetics
Elastomers
Tissue Scaffolds
Imaging techniques
Image communication systems
Refractometry
Biomedical Technology
Biodegradable polymers
Regenerative Medicine
Optical waveguides
Turbidity
Biodegradation
Sprague Dawley Rats
Rats
Refractive index

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Shan, Dingying ; Zhang, Chenji ; Kalaba, Surge ; Mehta, Nikhil ; Kim, Gloria B. ; Liu, Zhiwen ; Yang, Jian. / Flexible biodegradable citrate-based polymeric step-index optical fiber. In: Biomaterials. 2017 ; Vol. 143. pp. 142-148.
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Flexible biodegradable citrate-based polymeric step-index optical fiber. / Shan, Dingying; Zhang, Chenji; Kalaba, Surge; Mehta, Nikhil; Kim, Gloria B.; Liu, Zhiwen; Yang, Jian.

In: Biomaterials, Vol. 143, 01.10.2017, p. 142-148.

Research output: Contribution to journalArticle

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