Flipping a citrate switch on liver cancer cells

Research output: Contribution to journalReview article

Abstract

Energy homeostasis and oncogenic signaling are critical determinants of the growth of human liver cancer cells, providing a strong rationale to elucidate the regulatory mechanisms for these systems. A new study reports that loss of solute carrier family 13 member 5, which transports citrate across cell membranes, halts liver cancer cell growth by altering both energy production and mammalian target of rapamycin signaling in human liver cancer cell lines and in both an in vitro and in vivo model of liver tumors, suggesting a new target for liver cancer chemoprevention and/or chemotherapy.

Original languageEnglish (US)
Pages (from-to)13902-13903
Number of pages2
JournalJournal of Biological Chemistry
Volume292
Issue number33
DOIs
StatePublished - Jan 1 2017

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Liver Neoplasms
Citric Acid
Liver
Cells
Switches
Chemoprevention
Sirolimus
Growth
Chemotherapy
Cell growth
Cell membranes
Homeostasis
Cell Membrane
Tumors
Drug Therapy
Cell Line
Neoplasms

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Molecular Biology
  • Cell Biology

Cite this

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Flipping a citrate switch on liver cancer cells. / Peters, Jeffrey Maurice.

In: Journal of Biological Chemistry, Vol. 292, No. 33, 01.01.2017, p. 13902-13903.

Research output: Contribution to journalReview article

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AU - Peters, Jeffrey Maurice

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Y1 - 2017/1/1

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