Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling

G. A. Giridharan, C. Lederer, A. Berthe, L. Goubergrits, J. Hutzenlaub, M. S. Slaughter, R. D. Dowling, P. A. Spence, S. C. Koenig

Research output: Contribution to journalArticle

18 Citations (Scopus)

Abstract

Background: Historically, single port valveless pneumatic blood pumps have had a high incidence of thrombus formation due to areas of blood stagnation and hemolysis due to areas of high shear stress. Methods: To ensure minimal hemolysis and favorable blood washing characteristics, particle image velocimetry (PIV) and computational fluid dynamics (CFD) were used to evaluate the design of a new single port, valveless counterpulsation device (Symphony). The Symphony design was tested in 6-h acute (n= 8), 5-day (n= 8) and 30-day (n= 2) chronic experiments in a calf model (Jersey, 76. kg). Venous blood samples were collected during acute (hourly) and chronic (weekly) time courses to analyze for temporal changes in biochemical markers and quantify plasma free hemoglobin. At the end of the study, animals were euthanized and the Symphony and end-organs (brain, liver, kidney, lungs, heart, and spleen) were examined for thrombus formations. Results: Both the PIV and the CFD showed the development of a strong moving vortex during filling phase and that blood exited the Symphony uniformly from all areas during ejection phase. The laminar shear stresses estimated by CFD remained well below the hemolysis threshold of 400. Pa inside the Symphony throughout filling and ejection phases. No areas of persistent blood stagnation or flow separation were observed. The maximum plasma free hemoglobin (<10. mg/dl), average platelet count (pre-implant = 473 ± 56. K/μl and post-implant = 331 ± 62. K/μl), and average hematocrit (pre-implant = 31 ± 2% and post-implant = 29 ± 2%) were normal at all measured time-points for each test animal in acute and chronic experiments. There were no changes in measures of hepatic function (ALP, ALT) or renal function (creatinine) from pre-Symphony implantation values. The necropsy examination showed no signs of thrombus formation in the Symphony or end organs. Conclusions: These data suggest that the designed Symphony has good washing characteristics without persistent areas of blood stagnation sites during the entire pump cycle, and has a low risk of hemolysis and thrombus formations.

Original languageEnglish (US)
Pages (from-to)1193-1202
Number of pages10
JournalMedical Engineering and Physics
Volume33
Issue number10
DOIs
StatePublished - Dec 1 2011

Fingerprint

Counterpulsation
Rheology
Hydrodynamics
Velocity measurement
Computational fluid dynamics
Blood
Equipment and Supplies
Hemolysis
Thrombosis
Hemoglobin
Washing
Shear stress
Hemoglobins
Animals
Pumps
Kidney
Plasmas
Flow separation
Liver
Platelets

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Biomedical Engineering

Cite this

Giridharan, G. A., Lederer, C., Berthe, A., Goubergrits, L., Hutzenlaub, J., Slaughter, M. S., ... Koenig, S. C. (2011). Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling. Medical Engineering and Physics, 33(10), 1193-1202. https://doi.org/10.1016/j.medengphy.2011.05.008
Giridharan, G. A. ; Lederer, C. ; Berthe, A. ; Goubergrits, L. ; Hutzenlaub, J. ; Slaughter, M. S. ; Dowling, R. D. ; Spence, P. A. ; Koenig, S. C. / Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling. In: Medical Engineering and Physics. 2011 ; Vol. 33, No. 10. pp. 1193-1202.
@article{25fb83259d7447248e4e5bf017aed120,
title = "Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling",
abstract = "Background: Historically, single port valveless pneumatic blood pumps have had a high incidence of thrombus formation due to areas of blood stagnation and hemolysis due to areas of high shear stress. Methods: To ensure minimal hemolysis and favorable blood washing characteristics, particle image velocimetry (PIV) and computational fluid dynamics (CFD) were used to evaluate the design of a new single port, valveless counterpulsation device (Symphony). The Symphony design was tested in 6-h acute (n= 8), 5-day (n= 8) and 30-day (n= 2) chronic experiments in a calf model (Jersey, 76. kg). Venous blood samples were collected during acute (hourly) and chronic (weekly) time courses to analyze for temporal changes in biochemical markers and quantify plasma free hemoglobin. At the end of the study, animals were euthanized and the Symphony and end-organs (brain, liver, kidney, lungs, heart, and spleen) were examined for thrombus formations. Results: Both the PIV and the CFD showed the development of a strong moving vortex during filling phase and that blood exited the Symphony uniformly from all areas during ejection phase. The laminar shear stresses estimated by CFD remained well below the hemolysis threshold of 400. Pa inside the Symphony throughout filling and ejection phases. No areas of persistent blood stagnation or flow separation were observed. The maximum plasma free hemoglobin (<10. mg/dl), average platelet count (pre-implant = 473 ± 56. K/μl and post-implant = 331 ± 62. K/μl), and average hematocrit (pre-implant = 31 ± 2{\%} and post-implant = 29 ± 2{\%}) were normal at all measured time-points for each test animal in acute and chronic experiments. There were no changes in measures of hepatic function (ALP, ALT) or renal function (creatinine) from pre-Symphony implantation values. The necropsy examination showed no signs of thrombus formation in the Symphony or end organs. Conclusions: These data suggest that the designed Symphony has good washing characteristics without persistent areas of blood stagnation sites during the entire pump cycle, and has a low risk of hemolysis and thrombus formations.",
author = "Giridharan, {G. A.} and C. Lederer and A. Berthe and L. Goubergrits and J. Hutzenlaub and Slaughter, {M. S.} and Dowling, {R. D.} and Spence, {P. A.} and Koenig, {S. C.}",
year = "2011",
month = "12",
day = "1",
doi = "10.1016/j.medengphy.2011.05.008",
language = "English (US)",
volume = "33",
pages = "1193--1202",
journal = "Medical Engineering and Physics",
issn = "1350-4533",
publisher = "Elsevier BV",
number = "10",

}

Giridharan, GA, Lederer, C, Berthe, A, Goubergrits, L, Hutzenlaub, J, Slaughter, MS, Dowling, RD, Spence, PA & Koenig, SC 2011, 'Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling', Medical Engineering and Physics, vol. 33, no. 10, pp. 1193-1202. https://doi.org/10.1016/j.medengphy.2011.05.008

Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling. / Giridharan, G. A.; Lederer, C.; Berthe, A.; Goubergrits, L.; Hutzenlaub, J.; Slaughter, M. S.; Dowling, R. D.; Spence, P. A.; Koenig, S. C.

In: Medical Engineering and Physics, Vol. 33, No. 10, 01.12.2011, p. 1193-1202.

Research output: Contribution to journalArticle

TY - JOUR

T1 - Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling

AU - Giridharan, G. A.

AU - Lederer, C.

AU - Berthe, A.

AU - Goubergrits, L.

AU - Hutzenlaub, J.

AU - Slaughter, M. S.

AU - Dowling, R. D.

AU - Spence, P. A.

AU - Koenig, S. C.

PY - 2011/12/1

Y1 - 2011/12/1

N2 - Background: Historically, single port valveless pneumatic blood pumps have had a high incidence of thrombus formation due to areas of blood stagnation and hemolysis due to areas of high shear stress. Methods: To ensure minimal hemolysis and favorable blood washing characteristics, particle image velocimetry (PIV) and computational fluid dynamics (CFD) were used to evaluate the design of a new single port, valveless counterpulsation device (Symphony). The Symphony design was tested in 6-h acute (n= 8), 5-day (n= 8) and 30-day (n= 2) chronic experiments in a calf model (Jersey, 76. kg). Venous blood samples were collected during acute (hourly) and chronic (weekly) time courses to analyze for temporal changes in biochemical markers and quantify plasma free hemoglobin. At the end of the study, animals were euthanized and the Symphony and end-organs (brain, liver, kidney, lungs, heart, and spleen) were examined for thrombus formations. Results: Both the PIV and the CFD showed the development of a strong moving vortex during filling phase and that blood exited the Symphony uniformly from all areas during ejection phase. The laminar shear stresses estimated by CFD remained well below the hemolysis threshold of 400. Pa inside the Symphony throughout filling and ejection phases. No areas of persistent blood stagnation or flow separation were observed. The maximum plasma free hemoglobin (<10. mg/dl), average platelet count (pre-implant = 473 ± 56. K/μl and post-implant = 331 ± 62. K/μl), and average hematocrit (pre-implant = 31 ± 2% and post-implant = 29 ± 2%) were normal at all measured time-points for each test animal in acute and chronic experiments. There were no changes in measures of hepatic function (ALP, ALT) or renal function (creatinine) from pre-Symphony implantation values. The necropsy examination showed no signs of thrombus formation in the Symphony or end organs. Conclusions: These data suggest that the designed Symphony has good washing characteristics without persistent areas of blood stagnation sites during the entire pump cycle, and has a low risk of hemolysis and thrombus formations.

AB - Background: Historically, single port valveless pneumatic blood pumps have had a high incidence of thrombus formation due to areas of blood stagnation and hemolysis due to areas of high shear stress. Methods: To ensure minimal hemolysis and favorable blood washing characteristics, particle image velocimetry (PIV) and computational fluid dynamics (CFD) were used to evaluate the design of a new single port, valveless counterpulsation device (Symphony). The Symphony design was tested in 6-h acute (n= 8), 5-day (n= 8) and 30-day (n= 2) chronic experiments in a calf model (Jersey, 76. kg). Venous blood samples were collected during acute (hourly) and chronic (weekly) time courses to analyze for temporal changes in biochemical markers and quantify plasma free hemoglobin. At the end of the study, animals were euthanized and the Symphony and end-organs (brain, liver, kidney, lungs, heart, and spleen) were examined for thrombus formations. Results: Both the PIV and the CFD showed the development of a strong moving vortex during filling phase and that blood exited the Symphony uniformly from all areas during ejection phase. The laminar shear stresses estimated by CFD remained well below the hemolysis threshold of 400. Pa inside the Symphony throughout filling and ejection phases. No areas of persistent blood stagnation or flow separation were observed. The maximum plasma free hemoglobin (<10. mg/dl), average platelet count (pre-implant = 473 ± 56. K/μl and post-implant = 331 ± 62. K/μl), and average hematocrit (pre-implant = 31 ± 2% and post-implant = 29 ± 2%) were normal at all measured time-points for each test animal in acute and chronic experiments. There were no changes in measures of hepatic function (ALP, ALT) or renal function (creatinine) from pre-Symphony implantation values. The necropsy examination showed no signs of thrombus formation in the Symphony or end organs. Conclusions: These data suggest that the designed Symphony has good washing characteristics without persistent areas of blood stagnation sites during the entire pump cycle, and has a low risk of hemolysis and thrombus formations.

UR - http://www.scopus.com/inward/record.url?scp=82755161022&partnerID=8YFLogxK

UR - http://www.scopus.com/inward/citedby.url?scp=82755161022&partnerID=8YFLogxK

U2 - 10.1016/j.medengphy.2011.05.008

DO - 10.1016/j.medengphy.2011.05.008

M3 - Article

C2 - 21680224

AN - SCOPUS:82755161022

VL - 33

SP - 1193

EP - 1202

JO - Medical Engineering and Physics

JF - Medical Engineering and Physics

SN - 1350-4533

IS - 10

ER -

Giridharan GA, Lederer C, Berthe A, Goubergrits L, Hutzenlaub J, Slaughter MS et al. Flow dynamics of a novel counterpulsation device characterized by CFD and PIV modeling. Medical Engineering and Physics. 2011 Dec 1;33(10):1193-1202. https://doi.org/10.1016/j.medengphy.2011.05.008