Background. Abnormalities in endothelium-dependent relaxation to acetylcholine have been reported in congestive heart failure (CHF). The purpose of this study was to determine whether there are abnormalities in flow-mediated large vessel relaxation in patients with chronic CHF. Methods and Results. The dilator response of the radial artery was measured by a new high precision A-mode ultrasound device in response to release of 10 minutes of forearm arterial occlusion (reactive hyperemic blood flow response, RHBF). Radial arterial blood velocity was measured simultaneously, and blood flow was calculated. In nine patients with chronic CHF, there was a small but insignificant reduction of peak RHFB (p=0.09) when compared with nine age- matched control subjects. The increase in arterial diameter that followed the peak blood flow was significantly reduced in CHF (normal: 14.98±2.47%; CHF: 7.58±0.89%; p<0.01). In addition, the time to peak arterial relaxation was delayed (normal: 57.8±9.4 seconds; CHF: 98.9±15 seconds; p<0.02). When the peak percent increase in diameter was divided by the magnitude of the peak blood flow response, differences in the CHF and normal groups persisted. Conclusions. These data indicate that flow-mediated large artery relaxation is abnormal in CHF. It is suggested that both structural and endothelium- dependent abnormalities may contribute to this abnormal response.
|Original language||English (US)|
|Issue number||6 SUPPL. VII|
|State||Published - Jan 1 1993|
All Science Journal Classification (ASJC) codes
- Cardiology and Cardiovascular Medicine
- Physiology (medical)