Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning

Breigh N. Roszelle, Steven Deutsch, William J. Weiss, Keefe B. Manning

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

The aim of this study is to define the fluid mechanics of a pulsatile pneumatically driven pediatric ventricular assist device (PVAD), for the reduced flow rates encountered during device weaning and myocardial recovery, and relate the results to the potential for thromboembolic events. We place an acrylic model of the PVAD in a mock circulatory loop filled with a viscoelastic blood analog and operate at four stroke volumes (SVs), each with two different filling conditions, to mimic how the flow rate of the device may be reduced. Particle image velocimetry is used to acquire flow field data. We find that a SV reduction method provides better rotational flow and higher wall shear rates than a beat rate reduction method; that a quick filling condition with a compressed diastolic time is better than a slow filling condition; and, that a reduction in SV to 40% led to greatly reduced fluid movement and wall shear rates that could increase the thrombogenicity of the device. SV reduction is a viable option for flow reduction during weaning, however, it does lead to significant changes to the device flow field and future studies are needed to develop operational protocols for the PVAD during bridge-to-recovery.

Original languageEnglish (US)
Pages (from-to)2046-2058
Number of pages13
JournalAnnals of Biomedical Engineering
Volume39
Issue number7
DOIs
StatePublished - Jul 1 2011

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Pediatrics
Flow visualization
Shear deformation
Flow fields
Flow rate
Rotational flow
Recovery
Fluid mechanics
Velocity measurement
Acrylics
Blood
Fluids

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering

Cite this

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Flow visualization of a pediatric ventricular assist device during stroke volume reductions related to weaning. / Roszelle, Breigh N.; Deutsch, Steven; Weiss, William J.; Manning, Keefe B.

In: Annals of Biomedical Engineering, Vol. 39, No. 7, 01.07.2011, p. 2046-2058.

Research output: Contribution to journalArticle

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