Fluid dynamic analysis of the 50 cc Penn State artificial heart under physiological operating conditions using particle image velocimetry

Pramote Hochareon, Keefe B. Manning, Arnold A. Fontaine, John M. Tarbell, Steven Deutsch

Research output: Contribution to journalArticle

26 Citations (Scopus)

Abstract

In order to bridge the gap of existing artificial heart technology to the diverse needs of the patient population, we have been investigating the viability of a scaled-down design of the current 70 cc Penn State artificial heart. The issues of clot formation and hemolysis may become magnified within a 50 cc chamber compared to the existing 70 cc one. Particle image velocimetry (PIV) was employed to map the entire 50 cc Penn State artificial heart chamber. Flow fields constructed from PIV data indicate a rotational flow pattern that provides washout during diastole. In addition, shear rate maps were constructed for the inner walls of the heart chamber. The lateral walls of the mitral and aortic ports experience high shear rates while the upper and bottom walls undergo low shear rates, with sufficiently long exposure times to potentially induce platelet activation or thrombus formation. In this study, we have demonstrated that PIV may adequately map the flow fields accurately in a reasonable amount of time. Therefore, the potential exists of employing PIV as a design tool.

Original languageEnglish (US)
Pages (from-to)585-593
Number of pages9
JournalJournal of Biomechanical Engineering
Volume126
Issue number5
DOIs
StatePublished - Oct 1 2004

Fingerprint

Artificial heart
Artificial Heart
Rheology
Hydrodynamics
Fluid dynamics
Velocity measurement
Dynamic analysis
Shear deformation
Flow fields
Rotational flow
Diastole
Platelet Activation
Platelets
Hemolysis
Flow patterns
Thrombosis
Chemical activation
Technology
Population

All Science Journal Classification (ASJC) codes

  • Biomedical Engineering
  • Physiology (medical)

Cite this

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abstract = "In order to bridge the gap of existing artificial heart technology to the diverse needs of the patient population, we have been investigating the viability of a scaled-down design of the current 70 cc Penn State artificial heart. The issues of clot formation and hemolysis may become magnified within a 50 cc chamber compared to the existing 70 cc one. Particle image velocimetry (PIV) was employed to map the entire 50 cc Penn State artificial heart chamber. Flow fields constructed from PIV data indicate a rotational flow pattern that provides washout during diastole. In addition, shear rate maps were constructed for the inner walls of the heart chamber. The lateral walls of the mitral and aortic ports experience high shear rates while the upper and bottom walls undergo low shear rates, with sufficiently long exposure times to potentially induce platelet activation or thrombus formation. In this study, we have demonstrated that PIV may adequately map the flow fields accurately in a reasonable amount of time. Therefore, the potential exists of employing PIV as a design tool.",
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Fluid dynamic analysis of the 50 cc Penn State artificial heart under physiological operating conditions using particle image velocimetry. / Hochareon, Pramote; Manning, Keefe B.; Fontaine, Arnold A.; Tarbell, John M.; Deutsch, Steven.

In: Journal of Biomechanical Engineering, Vol. 126, No. 5, 01.10.2004, p. 585-593.

Research output: Contribution to journalArticle

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