Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers

Yi Zhang, Richard T. Tran, Ibrahim S. Qattan, Yi Ting Tsai, Liping Tang, Chao Liu, Jian Yang

Research output: Contribution to journalArticle

41 Citations (Scopus)

Abstract

The field of tissue engineering and drug delivery calls for new measurement tools, non-invasive real-time assays, and design methods for the next wave of innovations. Based on our recent progress in developing intrinsically biodegradable photoluminescent polymers (BPLPs) without conjugating organic dyes or quantum dots, in this paper, we developed a new type urethane-doped biodegradable photoluminescent polymers (UBPLPs) that could potentially serve as a new tool to respond the above call for innovations. Inherited from BPLPs, UBPLPs demonstrated strong inherent photoluminescence and excellent cytocompatibility in vitro. Crosslinked UBPLPs (CUBPLPs) showed soft, elastic, but strong mechanical properties with a tensile strength as high as 49.41 ± 6.17 MPa and a corresponding elongation at break of 334.87 ± 26.31%. Porous triphasic CUBPLP vascular scaffolds showed a burst pressure of 769.33 ± 70.88 mmHg and a suture retention strength of 1.79 ± 0.11 N. Stable but photoluminescent nanoparticles with average size of 103 nm were also obtained by nanoprecipitation. High loading efficiency (91.84%) and sustained release of 5-fluorouracil (up to 120 h) were achieved from UBPLP nanoparticles. With a quantum yield as high as 38.65%, both triphasic scaffold and nanoparticle solutions could be non-invasively detected in vivo. UBPLPs represent an innovation in fluorescent biomaterial design and may offer great potential in advancing the field of tissue engineering and drug delivery where bioimaging has gained increasing interest.

Original languageEnglish (US)
Pages (from-to)4048-4056
Number of pages9
JournalBiomaterials
Volume34
Issue number16
DOIs
StatePublished - May 1 2013

Fingerprint

Elastomers
Biodegradable polymers
Optical Imaging
Urethane
Citric Acid
Polymers
Fluorescence
Imaging techniques
Nanoparticles
Innovation
Tissue Engineering
Drug delivery
Tissue engineering
Scaffolds
Quantum Dots
Tensile Strength
Bioelectric potentials
Biocompatible Materials
Quantum yield
Biomaterials

All Science Journal Classification (ASJC) codes

  • Bioengineering
  • Ceramics and Composites
  • Biophysics
  • Biomaterials
  • Mechanics of Materials

Cite this

Zhang, Yi ; Tran, Richard T. ; Qattan, Ibrahim S. ; Tsai, Yi Ting ; Tang, Liping ; Liu, Chao ; Yang, Jian. / Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers. In: Biomaterials. 2013 ; Vol. 34, No. 16. pp. 4048-4056.
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Fluorescence imaging enabled urethane-doped citrate-based biodegradable elastomers. / Zhang, Yi; Tran, Richard T.; Qattan, Ibrahim S.; Tsai, Yi Ting; Tang, Liping; Liu, Chao; Yang, Jian.

In: Biomaterials, Vol. 34, No. 16, 01.05.2013, p. 4048-4056.

Research output: Contribution to journalArticle

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