Fluorometric assay of bethanidine in plasma

C. N. Corder, T. S. Klaniecki, R. H. Mc Donald, C. Berlin

Research output: Contribution to journalArticle

4 Scopus citations

Abstract

A fluorometric method for determining bethanidine in blood plasma is described. The bethanidine is extracted into chloroform, a drug‐dye complex with eosin Y is formed, and the fluorescence is measured (excitation, 535 nm; fluorescence, 560 nm). The assay detects 0.02 μM bethanidine (4 ng/ml) in plasma. The relative fluorescence of several body constituents and antihypertensive drugs is negligible. The plasma levels of bethanidine in four hypertensive patients receiving this drug were measured.

Original languageEnglish (US)
Pages (from-to)785-788
Number of pages4
JournalJournal of Pharmaceutical Sciences
Volume64
Issue number5
DOIs
StatePublished - May 1975

All Science Journal Classification (ASJC) codes

  • Pharmaceutical Science

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    Corder, C. N., Klaniecki, T. S., Mc Donald, R. H., & Berlin, C. (1975). Fluorometric assay of bethanidine in plasma. Journal of Pharmaceutical Sciences, 64(5), 785-788. https://doi.org/10.1002/jps.2600640511