23 Citations (Scopus)

Abstract

Food restriction was used to increase the life span of normotensive (WKY) and Spontaneously Hypertensive Rats (SHR). When SHR's were maintained on 40% of an otherwise typical lab rat diet, their mean life spans increased from 18 months to over 30 months. The mean life times of normotensive rats which were similarly food restricted were expanded from 24 months to over 32 months. Histological examination of heart, adrenals, kidneys and brain showed that freely fed hypertensive rats died of end-organ damage associated with high blood pressure. In contrast, deaths of food restricted hypertensive rats appeared due to changes associated with old age, rather than specific lesions due to hypertension. Thus, food restriction allows a genetically hypertensive animal to reach a normal life span and to die of age-related rather than hypertension-related events.

Original languageEnglish (US)
Pages (from-to)401-407
Number of pages7
JournalLife Sciences
Volume34
Issue number4
DOIs
StatePublished - Jan 23 1984

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Rats
Animals
Food
Hypertension
Inbred SHR Rats
Blood pressure
Nutrition
Diet
Brain
Kidney

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

Cite this

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title = "Food restriction increases life span of hypertensive animals",
abstract = "Food restriction was used to increase the life span of normotensive (WKY) and Spontaneously Hypertensive Rats (SHR). When SHR's were maintained on 40{\%} of an otherwise typical lab rat diet, their mean life spans increased from 18 months to over 30 months. The mean life times of normotensive rats which were similarly food restricted were expanded from 24 months to over 32 months. Histological examination of heart, adrenals, kidneys and brain showed that freely fed hypertensive rats died of end-organ damage associated with high blood pressure. In contrast, deaths of food restricted hypertensive rats appeared due to changes associated with old age, rather than specific lesions due to hypertension. Thus, food restriction allows a genetically hypertensive animal to reach a normal life span and to die of age-related rather than hypertension-related events.",
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Food restriction increases life span of hypertensive animals. / Lloyd, Tom.

In: Life Sciences, Vol. 34, No. 4, 23.01.1984, p. 401-407.

Research output: Contribution to journalArticle

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T1 - Food restriction increases life span of hypertensive animals

AU - Lloyd, Tom

PY - 1984/1/23

Y1 - 1984/1/23

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