Force Control Deficits in Individuals with Parkinson's Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy

Kristina A. Neely, Peggy J. Planetta, Janey Prodoehl, Daniel M. Corcos, Cynthia L. Comella, Christopher G. Goetz, Kathleen L. Shannon, David E. Vaillancourt

Research output: Contribution to journalArticle

20 Citations (Scopus)

Abstract

Objective: This study examined grip force and cognition in Parkinson's disease (PD), Parkinsonian variant of multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), and healthy controls. PD is characterized by a slower rate of force increase and decrease and the production of abnormally large grip forces. Early-stage PD has difficulty with the rapid contraction and relaxation of hand muscles required for precision gripping. The first goal was to determine which features of grip force are abnormal in MSAp and PSP. The second goal was to determine whether a single variable or a combination of motor and cognitive measures would distinguish patient groups. Since PSP is more cognitively impaired relative to PD and MSAp, we expected that combining motor and cognitive measures would further distinguish PSP from PD and MSAp. Methods: We studied 44 participants: 12 PD, 12 MSAp, 8 PSP, and 12 controls. Patients were diagnosed by a movement disorders neurologist and were tested off anti-Parkinsonian medication. Participants completed a visually guided grip force task wherein force pulses were produced for 2 s, followed by 1 s of rest. We also conducted four cognitive tests. Results: PD, MSAp, and PSP were slower at contracting and relaxing force and produced longer pulse durations compared to controls. PSP produced additional force pulses during the task and were more cognitively impaired relative to other groups. A receiver operator characteristic analysis revealed that the combination of number of pulses and Brief Test of Attention (BTA) discriminated PSP from PD, MSAp, and controls with a high degree of sensitivity and specificity. Conclusions: Slowness in contracting and relaxing force represent general features of PD, MSAp, and PSP, whereas producing additional force pulses was specific to PSP. Combining motor and cognitive measures provides a robust method for characterizing behavioral features of PSP compared to MSAp and PD.

Original languageEnglish (US)
Article numbere58403
JournalPloS one
Volume8
Issue number3
DOIs
StatePublished - Mar 11 2013

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Progressive Supranuclear Palsy
Multiple System Atrophy
Parkinson disease
Force control
paralysis
atrophy
Parkinson Disease
Hand Strength
movement disorders
Muscle Relaxation
Movement Disorders
Advisory Committees
cognition
Muscle
Cognition
drug therapy
hands
Hand
testing

All Science Journal Classification (ASJC) codes

  • Biochemistry, Genetics and Molecular Biology(all)
  • Agricultural and Biological Sciences(all)

Cite this

Neely, K. A., Planetta, P. J., Prodoehl, J., Corcos, D. M., Comella, C. L., Goetz, C. G., ... Vaillancourt, D. E. (2013). Force Control Deficits in Individuals with Parkinson's Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy. PloS one, 8(3), [e58403]. https://doi.org/10.1371/journal.pone.0058403
Neely, Kristina A. ; Planetta, Peggy J. ; Prodoehl, Janey ; Corcos, Daniel M. ; Comella, Cynthia L. ; Goetz, Christopher G. ; Shannon, Kathleen L. ; Vaillancourt, David E. / Force Control Deficits in Individuals with Parkinson's Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy. In: PloS one. 2013 ; Vol. 8, No. 3.
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abstract = "Objective: This study examined grip force and cognition in Parkinson's disease (PD), Parkinsonian variant of multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), and healthy controls. PD is characterized by a slower rate of force increase and decrease and the production of abnormally large grip forces. Early-stage PD has difficulty with the rapid contraction and relaxation of hand muscles required for precision gripping. The first goal was to determine which features of grip force are abnormal in MSAp and PSP. The second goal was to determine whether a single variable or a combination of motor and cognitive measures would distinguish patient groups. Since PSP is more cognitively impaired relative to PD and MSAp, we expected that combining motor and cognitive measures would further distinguish PSP from PD and MSAp. Methods: We studied 44 participants: 12 PD, 12 MSAp, 8 PSP, and 12 controls. Patients were diagnosed by a movement disorders neurologist and were tested off anti-Parkinsonian medication. Participants completed a visually guided grip force task wherein force pulses were produced for 2 s, followed by 1 s of rest. We also conducted four cognitive tests. Results: PD, MSAp, and PSP were slower at contracting and relaxing force and produced longer pulse durations compared to controls. PSP produced additional force pulses during the task and were more cognitively impaired relative to other groups. A receiver operator characteristic analysis revealed that the combination of number of pulses and Brief Test of Attention (BTA) discriminated PSP from PD, MSAp, and controls with a high degree of sensitivity and specificity. Conclusions: Slowness in contracting and relaxing force represent general features of PD, MSAp, and PSP, whereas producing additional force pulses was specific to PSP. Combining motor and cognitive measures provides a robust method for characterizing behavioral features of PSP compared to MSAp and PD.",
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Neely, KA, Planetta, PJ, Prodoehl, J, Corcos, DM, Comella, CL, Goetz, CG, Shannon, KL & Vaillancourt, DE 2013, 'Force Control Deficits in Individuals with Parkinson's Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy', PloS one, vol. 8, no. 3, e58403. https://doi.org/10.1371/journal.pone.0058403

Force Control Deficits in Individuals with Parkinson's Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy. / Neely, Kristina A.; Planetta, Peggy J.; Prodoehl, Janey; Corcos, Daniel M.; Comella, Cynthia L.; Goetz, Christopher G.; Shannon, Kathleen L.; Vaillancourt, David E.

In: PloS one, Vol. 8, No. 3, e58403, 11.03.2013.

Research output: Contribution to journalArticle

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T1 - Force Control Deficits in Individuals with Parkinson's Disease, Multiple Systems Atrophy, and Progressive Supranuclear Palsy

AU - Neely, Kristina A.

AU - Planetta, Peggy J.

AU - Prodoehl, Janey

AU - Corcos, Daniel M.

AU - Comella, Cynthia L.

AU - Goetz, Christopher G.

AU - Shannon, Kathleen L.

AU - Vaillancourt, David E.

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N2 - Objective: This study examined grip force and cognition in Parkinson's disease (PD), Parkinsonian variant of multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), and healthy controls. PD is characterized by a slower rate of force increase and decrease and the production of abnormally large grip forces. Early-stage PD has difficulty with the rapid contraction and relaxation of hand muscles required for precision gripping. The first goal was to determine which features of grip force are abnormal in MSAp and PSP. The second goal was to determine whether a single variable or a combination of motor and cognitive measures would distinguish patient groups. Since PSP is more cognitively impaired relative to PD and MSAp, we expected that combining motor and cognitive measures would further distinguish PSP from PD and MSAp. Methods: We studied 44 participants: 12 PD, 12 MSAp, 8 PSP, and 12 controls. Patients were diagnosed by a movement disorders neurologist and were tested off anti-Parkinsonian medication. Participants completed a visually guided grip force task wherein force pulses were produced for 2 s, followed by 1 s of rest. We also conducted four cognitive tests. Results: PD, MSAp, and PSP were slower at contracting and relaxing force and produced longer pulse durations compared to controls. PSP produced additional force pulses during the task and were more cognitively impaired relative to other groups. A receiver operator characteristic analysis revealed that the combination of number of pulses and Brief Test of Attention (BTA) discriminated PSP from PD, MSAp, and controls with a high degree of sensitivity and specificity. Conclusions: Slowness in contracting and relaxing force represent general features of PD, MSAp, and PSP, whereas producing additional force pulses was specific to PSP. Combining motor and cognitive measures provides a robust method for characterizing behavioral features of PSP compared to MSAp and PD.

AB - Objective: This study examined grip force and cognition in Parkinson's disease (PD), Parkinsonian variant of multiple system atrophy (MSAp), progressive supranuclear palsy (PSP), and healthy controls. PD is characterized by a slower rate of force increase and decrease and the production of abnormally large grip forces. Early-stage PD has difficulty with the rapid contraction and relaxation of hand muscles required for precision gripping. The first goal was to determine which features of grip force are abnormal in MSAp and PSP. The second goal was to determine whether a single variable or a combination of motor and cognitive measures would distinguish patient groups. Since PSP is more cognitively impaired relative to PD and MSAp, we expected that combining motor and cognitive measures would further distinguish PSP from PD and MSAp. Methods: We studied 44 participants: 12 PD, 12 MSAp, 8 PSP, and 12 controls. Patients were diagnosed by a movement disorders neurologist and were tested off anti-Parkinsonian medication. Participants completed a visually guided grip force task wherein force pulses were produced for 2 s, followed by 1 s of rest. We also conducted four cognitive tests. Results: PD, MSAp, and PSP were slower at contracting and relaxing force and produced longer pulse durations compared to controls. PSP produced additional force pulses during the task and were more cognitively impaired relative to other groups. A receiver operator characteristic analysis revealed that the combination of number of pulses and Brief Test of Attention (BTA) discriminated PSP from PD, MSAp, and controls with a high degree of sensitivity and specificity. Conclusions: Slowness in contracting and relaxing force represent general features of PD, MSAp, and PSP, whereas producing additional force pulses was specific to PSP. Combining motor and cognitive measures provides a robust method for characterizing behavioral features of PSP compared to MSAp and PD.

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