Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise

Lawrence Sinoway, Jeffrey Shenberger, Gretchen Leaman, Robert Zelis, Kristen Gray, Robert Baily, Urs Leuenberger

Research output: Contribution to journalArticle

57 Citations (Scopus)

Abstract

We previously demonstrated that nonfatiguing rhythmic forearm exercise at 25% maximal voluntary contraction (12 2-s contractions/min) evokes sympathoexcitation without significant engagement of metabolite-sensitive muscle afferents (B. A. Batman, J. C. Hardy, U. A. Leuenberger, M. B. Smith, Q. X. Yang, and L. I. Sinoway. J. Appl. Physiol. 76: 1077-1081, 1994). This is in contrast to the sympathetic nervous system responses observed during fatiguing static forearm exercise where metabolite-sensitive afferents are the key determinants of sympathetic activation. In this report we examined whether forearm exercise training would attenuate sympathetic nervous system responses to rhythmic forearm exercise. We measured heart rate, mean arterial blood pressure (MAP), muscle sympathetic nerve activity (microneurography), plasma norepinephrine (NE), and NE spillover and clearance (tritiated NE kinetics) during nonfatiguing rhythmic forearm exercise before and after a 4- wk unilateral forearm training paradigm. Training had no effect on forearm mass, maximal voluntary contraction, or heart rate but did attenuate the increase in MAP (increase in MAP: from 15.2 ± 1.8 before training to 11.4 ± 1.4 mmHg after training; P < 0.017), muscle sympathetic nerve activity (increase in bursts: from 10.8 ± 1.4 before training to 6.2 ± 1.1 bursts/min after training; P < 0.030), and the NE spillover (increase in arterial spillover: from 1.3 ± 0.2 before training to 0.6 ± 0.2 nmol · min-1 · m-2 after training, P < 0.014; increase in venous spillover: from 2.0 ± 0.6 before training to 1.0 ± 0.5 nmol · min-1 · m-2 after training, P < 0.037) seen in response to exercise performed by the trained forearm. Thus forearm training reduces sympathetic responses during a nonfatiguing rhythmic handgrip paradigm that does not engage muscle metaboreceptors. We speculate that this effect is due to a conditioning- induced reduction in mechanically sensitive muscle afferent discharge.

Original languageEnglish (US)
Pages (from-to)1778-1784
Number of pages7
JournalJournal of applied physiology
Volume81
Issue number4
DOIs
StatePublished - Oct 1996

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Forearm
Arterial Pressure
Norepinephrine
Muscles
Sympathetic Nervous System
Heart Rate
Exercise

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)

Cite this

Sinoway, Lawrence ; Shenberger, Jeffrey ; Leaman, Gretchen ; Zelis, Robert ; Gray, Kristen ; Baily, Robert ; Leuenberger, Urs. / Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. In: Journal of applied physiology. 1996 ; Vol. 81, No. 4. pp. 1778-1784.
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abstract = "We previously demonstrated that nonfatiguing rhythmic forearm exercise at 25{\%} maximal voluntary contraction (12 2-s contractions/min) evokes sympathoexcitation without significant engagement of metabolite-sensitive muscle afferents (B. A. Batman, J. C. Hardy, U. A. Leuenberger, M. B. Smith, Q. X. Yang, and L. I. Sinoway. J. Appl. Physiol. 76: 1077-1081, 1994). This is in contrast to the sympathetic nervous system responses observed during fatiguing static forearm exercise where metabolite-sensitive afferents are the key determinants of sympathetic activation. In this report we examined whether forearm exercise training would attenuate sympathetic nervous system responses to rhythmic forearm exercise. We measured heart rate, mean arterial blood pressure (MAP), muscle sympathetic nerve activity (microneurography), plasma norepinephrine (NE), and NE spillover and clearance (tritiated NE kinetics) during nonfatiguing rhythmic forearm exercise before and after a 4- wk unilateral forearm training paradigm. Training had no effect on forearm mass, maximal voluntary contraction, or heart rate but did attenuate the increase in MAP (increase in MAP: from 15.2 ± 1.8 before training to 11.4 ± 1.4 mmHg after training; P < 0.017), muscle sympathetic nerve activity (increase in bursts: from 10.8 ± 1.4 before training to 6.2 ± 1.1 bursts/min after training; P < 0.030), and the NE spillover (increase in arterial spillover: from 1.3 ± 0.2 before training to 0.6 ± 0.2 nmol · min-1 · m-2 after training, P < 0.014; increase in venous spillover: from 2.0 ± 0.6 before training to 1.0 ± 0.5 nmol · min-1 · m-2 after training, P < 0.037) seen in response to exercise performed by the trained forearm. Thus forearm training reduces sympathetic responses during a nonfatiguing rhythmic handgrip paradigm that does not engage muscle metaboreceptors. We speculate that this effect is due to a conditioning- induced reduction in mechanically sensitive muscle afferent discharge.",
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Forearm training attenuates sympathetic responses to prolonged rhythmic forearm exercise. / Sinoway, Lawrence; Shenberger, Jeffrey; Leaman, Gretchen; Zelis, Robert; Gray, Kristen; Baily, Robert; Leuenberger, Urs.

In: Journal of applied physiology, Vol. 81, No. 4, 10.1996, p. 1778-1784.

Research output: Contribution to journalArticle

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