Forearm training reduces the exercise pressor reflex during ischemic rhythmic handgrip

Sogol Mostoufi-Moab, Eric J. Widmaier, Jacob A. Cornett, Kristen Gray, Lawrence I. Sinoway

Research output: Contribution to journalArticlepeer-review

53 Scopus citations


We examined the effects of unilateral, nondominant forearm training (4 wk) on blood pressure and forearm metabolites during ischemic and nonischemic rhythmic handgrip (30 1-s contractions/min at 25% maximal voluntary contraction). Contractions were performed by 10 subjects with the forearm enclosed in a pressurized Plexiglas tank to induce ischemic conditions. Training increased the endurance time in the nondominant arm by 102% (protocol 1). In protocol 2, tank pressure was increased in increments of 10 mmHg/min to +50 mmHg. Training raised the positive-pressure threshold necessary to engage the pressor response. In protocol 3, handgrip was performed at +50 mmHg and venous blood samples were analyzed. Training attenuated mean arterial pressure (109 ± 5 and 98 ± 4 mmHg pre- and posttraining, respectively, P < 0.01), venous lactate (2.9 ± 0.4 and 1.8 ± 0.3 mmol/1 pre- and posttraining, respectively, P < 0.01), and the pH response (7.21 ± 0.02 and 7.25 ± 0.01, pre- and posttraining, respectively, P < 0.01). However, deep venous O2 saturation was unchanged. Training increased the positive-pressure threshold for metaboreceptor engagement, reduced metabolite concentrations, and reduced mean arterial pressure during ischemic exercise.

Original languageEnglish (US)
Pages (from-to)277-283
Number of pages7
JournalJournal of applied physiology
Issue number1
StatePublished - Jan 1998

All Science Journal Classification (ASJC) codes

  • Physiology
  • Physiology (medical)


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