Forging Ahead through Darkness: PCNA, Still the Principal Conductor at the Replication Fork

Katherine N. Choe, George Lucian Moldovan

Research output: Contribution to journalReview articlepeer-review

113 Scopus citations

Abstract

Proliferating cell nuclear antigen (PCNA) lies at the center of the faithful duplication of eukaryotic genomes. With its distinctive doughnut-shaped molecular structure, PCNA was originally studied for its role in stimulating DNA polymerases. However, we now know that PCNA does much more than promote processive DNA synthesis. Because of the complexity of the events involved, cellular DNA replication poses major threats to genomic integrity. Whatever predicament lies ahead for the replication fork, PCNA is there to orchestrate the events necessary to handle it. Through its many protein interactions and various post-translational modifications, PCNA has far-reaching impacts on a myriad of cellular functions.

Original languageEnglish (US)
Pages (from-to)380-392
Number of pages13
JournalMolecular cell
Volume65
Issue number3
DOIs
StatePublished - Feb 2 2017

All Science Journal Classification (ASJC) codes

  • Molecular Biology
  • Cell Biology

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