Formate dehydrogenase

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Formate is a substrate, or product, of diverse reactions catalyzed by eukaryotic organisms, eubacteria, and archaebacteria. A survey of metabolic groups reveals that formate is a common growth substrate, especially among the anaerobic eubacteria and archaebacteria. Formate also functions as an accessory reductant for the utilization of more complex substrates, and an intermediate in energy-conserving pathways. The diversity of reactions involving formate dehydrogenesis is apparent in the structures of electron acceptors which include pyridine nucleotides, 5-deazaflavin, quinones, and ferredoxin. This diversity of electron acceptors is reflected in the composition of formate dehydrogenase. Studies on the enzymes have contributed to the biochemical and genetic understanding of selenium, molybdenum, tungsten, and iron in biology. The regulation of formate dehydrogenase synthesis serves as a model for understanding general principles of regulation in anaerobic organisms.

Original languageEnglish (US)
Pages (from-to)377-382
Number of pages6
JournalFEMS Microbiology Reviews
Volume87
Issue number3-4
StatePublished - Dec 1 1990

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formic acid
Formate Dehydrogenases
Archaea
Electrons
Bacteria
Ferredoxins
Quinones
Tungsten
Molybdenum
Reducing Agents
Selenium
Molecular Biology
Nucleotides
Iron
Enzymes
Growth

All Science Journal Classification (ASJC) codes

  • Microbiology
  • Infectious Diseases

Cite this

Ferry, James Gregory. / Formate dehydrogenase. In: FEMS Microbiology Reviews. 1990 ; Vol. 87, No. 3-4. pp. 377-382.
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Ferry, JG 1990, 'Formate dehydrogenase', FEMS Microbiology Reviews, vol. 87, no. 3-4, pp. 377-382.

Formate dehydrogenase. / Ferry, James Gregory.

In: FEMS Microbiology Reviews, Vol. 87, No. 3-4, 01.12.1990, p. 377-382.

Research output: Contribution to journalArticle

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