Formation of composites comprised of calcium deficient HAp and cross-linked gelatin

Ahmed H. Touny, Cato Laurencin, Lakshmi Nair, Harry R. Allcock, Paul W. Brown

Research output: Contribution to journalArticle

11 Citations (Scopus)

Abstract

Cross-linked gelatin/calcium deficient hydroxyapatite (CDHAp) composites were prepared at or near physiologic temperature. α-tricalcium phosphate (α-TCP) or a mixture of tetracalcium phosphate and dicalcium phosphate were used as CDHAp precursors. Glutaraldehyde was used to cross-link the gelatin fibers. CDHAp formation reached completion in the presence of cross-linked gelatin fibers. Effects of cross-linking concentrations, proportions of gelatin fiber, molecular weight of gelatin and the temperature of the hydration reaction on the formation of CDHAp were studied. Cross-linked gelatin acts as a nucleating agent for CDHAp formation. The pH variations during CDHAp formation are lower at the onset of the reactions in the presence of cross-linked gelatin fibers. Although cross-linked gelatin fibers enhance CDHAp formation their composites have low mechanical strengths. Swelling of gelatin appears to be a major factor that limits the strengths of the CDHAp/cross-linked gelatin composites.

Original languageEnglish (US)
Pages (from-to)3193-3201
Number of pages9
JournalJournal of Materials Science: Materials in Medicine
Volume19
Issue number10
DOIs
StatePublished - Oct 1 2008

Fingerprint

Gelatin
Hydroxyapatite
Calcium
Durapatite
Composite materials
Fibers
Phosphates
Temperature
Hydration
Strength of materials
Swelling
Glutaral
Molecular weight
Molecular Weight

All Science Journal Classification (ASJC) codes

  • Biophysics
  • Bioengineering
  • Biomaterials
  • Biomedical Engineering

Cite this

Touny, Ahmed H. ; Laurencin, Cato ; Nair, Lakshmi ; Allcock, Harry R. ; Brown, Paul W. / Formation of composites comprised of calcium deficient HAp and cross-linked gelatin. In: Journal of Materials Science: Materials in Medicine. 2008 ; Vol. 19, No. 10. pp. 3193-3201.
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Formation of composites comprised of calcium deficient HAp and cross-linked gelatin. / Touny, Ahmed H.; Laurencin, Cato; Nair, Lakshmi; Allcock, Harry R.; Brown, Paul W.

In: Journal of Materials Science: Materials in Medicine, Vol. 19, No. 10, 01.10.2008, p. 3193-3201.

Research output: Contribution to journalArticle

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AU - Laurencin, Cato

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AB - Cross-linked gelatin/calcium deficient hydroxyapatite (CDHAp) composites were prepared at or near physiologic temperature. α-tricalcium phosphate (α-TCP) or a mixture of tetracalcium phosphate and dicalcium phosphate were used as CDHAp precursors. Glutaraldehyde was used to cross-link the gelatin fibers. CDHAp formation reached completion in the presence of cross-linked gelatin fibers. Effects of cross-linking concentrations, proportions of gelatin fiber, molecular weight of gelatin and the temperature of the hydration reaction on the formation of CDHAp were studied. Cross-linked gelatin acts as a nucleating agent for CDHAp formation. The pH variations during CDHAp formation are lower at the onset of the reactions in the presence of cross-linked gelatin fibers. Although cross-linked gelatin fibers enhance CDHAp formation their composites have low mechanical strengths. Swelling of gelatin appears to be a major factor that limits the strengths of the CDHAp/cross-linked gelatin composites.

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