FORMATION OF PHOTOPRODUCTS LETHAL FOR HUMAN CELLS IN CULTURE BY DAYLIGHT FLUORESCENT LIGHT AND BILIRUBIN LIGHT

B. Tracy Nixon, Richard J. Wang

Research output: Contribution to journalEditorial

44 Scopus citations

Abstract

Abstract. Irradiation of Dulbecco's modified Eagle's tissue culture medium with “Daylight,”“Special Blue,” or “Bilirubin” fluorescent light produces photoproducts lethal to human cells. Killing is abolished when (1) riboflavin, (2) tryptophan and tyrosine, or (3) riboflavin, tryptophan and tyrosine are deleted from medium prior to irradiation with any of the above fluorescent lamps. Toxic photoproducts are also formed when buffered salt solutions containing (a) riboflavin and tryptophan, (b) riboflavin and tyrosine, or (c) riboflavin, tryptophan and tyrosine are exposed to any of these light sources.

Original languageEnglish (US)
Pages (from-to)589-593
Number of pages5
JournalPhotochemistry and Photobiology
Volume26
Issue number6
DOIs
StatePublished - Dec 1977

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Physical and Theoretical Chemistry

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