Forming and waking dormant cells: The ppGpp ribosome dimerization persister model

Thomas K. Wood, Sooyeon Song

Research output: Contribution to journalArticlepeer-review

17 Scopus citations

Abstract

Procaryotes starve and face myriad stresses. The bulk population actively resists the stress, but a small population weathers the stress by entering a resting stage known as persistence. No mutations occur, and so persisters behave like wild-type cells upon removal of the stress and regrowth; hence, persisters are phenotypic variants. In contrast, resistant bacteria have mutations that allow cells to grow in the presence of antibiotics, and tolerant cells survive antibiotics better than actively-growing cells due to their slow growth (such as that of the stationary phase). In this review, we focus on the latest developments in studies related to the formation and resuscitation of persister cells and propose the guanosine pentaphosphate/tetraphosphate (henceforth ppGpp) ribosome dimerization persister (PRDP) model for entering and exiting the persister state.

Original languageEnglish (US)
Article number100018
JournalBiofilm
Volume2
DOIs
StatePublished - Dec 2020

All Science Journal Classification (ASJC) codes

  • Applied Microbiology and Biotechnology
  • Microbiology
  • Cell Biology
  • Molecular Biology

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