Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety

Kelly M. Ness, Stephen M. Strayer, Nicole G. Nahmod, Margeaux M. Schade, Anne Marie Chang, Gregory C. Shearer, Orfeu M. Buxton

Research output: Contribution to journalArticlepeer-review

1 Scopus citations

Abstract

Chronic sleep restriction, or inadequate sleep, is associated with increased risk of cardiometabolic disease. Laboratory studies demonstrate that sleep restriction causes impaired whole-body insulin sensitivity and glucose disposal. Evidence suggests that inadequate sleep also impairs adipose tissue insulin sensitivity and the NEFA rebound during intravenous glucose tolerance tests, yet no studies have examined the effects of sleep restriction on high-fat meal lipemia. We assessed the effect of 5 h time in bed (TIB) per night for four consecutive nights on postprandial lipemia following a standardized high-fat dinner (HFD). Furthermore, we assessed whether one night of recovery sleep (10 h TIB) was sufficient to restore postprandial metabolism to baseline. We found that postprandial triglyceride (TG) area under the curve was suppressed by sleep restriction (P = 0.01), but returned to baseline values following one night of recovery. Sleep restriction decreased NEFAs throughout the HFD (P = 0.02) and NEFAs remained suppressed in the recovery condition (P = 0.04). Sleep restriction also decreased participant-reported fullness or satiety (P = 0.03), and decreased postprandial interleukin-6 (P < 0.01). Our findings indicate that four nights of 5 h TIB per night impair postprandial lipemia and that one night of recovery sleep may be adequate for recovery of TG metabolism, but not for markers of adipocyte function.

Original languageEnglish (US)
Pages (from-to)1935-1945
Number of pages11
JournalJournal of Lipid Research
Volume60
Issue number11
DOIs
StatePublished - 2019

All Science Journal Classification (ASJC) codes

  • Biochemistry
  • Endocrinology
  • Cell Biology

Fingerprint Dive into the research topics of 'Four nights of sleep restriction suppress the postprandial lipemic response and decrease satiety'. Together they form a unique fingerprint.

Cite this