FOXA2 promotes prostate cancer growth in the bone

Zachary M. Connelly, Renjie Jin, Jianghong Zhang, Shu Yang, Siyuan Cheng, Mingxia Shi, Justin M.M. Cates, Runhua Shi, David J. DeGraff, Peter S. Nelson, Yunlong Liu, Colm Morrissey, Eva Corey, Xiuping Yu

Research output: Contribution to journalArticlepeer-review

Abstract

Bone metastasis frequently occurs in advanced-stage prostate cancer (PCa) patients. Understanding the mechanisms that promote PCa-mediated bone destruction is important for the identification of therapeutic targets against this lethal disease. We found that forkhead box A2 (FOXA2) is expressed in a subset of PCa bone metastasis specimens. To determine the functional role of FOXA2 in PCa metastasis, we knocked down the expression of FOXA2 in PCa PC3 cells, which can grow in bones and elicit an osteolytic reaction. The PC3/FOXA2-knockdown cells generated fewer bone lesions following intra-tibial injection compared to control cells. Further, we found that FOXA2 knockdown decreased the expression of PTHLH, which encodes PTHrP, a well-established factor that regulates bone remodeling. These results indicate that FOXA2 is involved in PCa bone metastasis.

Original languageEnglish (US)
Pages (from-to)5619-5629
Number of pages11
JournalAmerican Journal of Translational Research
Volume12
Issue number9
StatePublished - 2020

All Science Journal Classification (ASJC) codes

  • Molecular Medicine
  • Clinical Biochemistry
  • Cancer Research

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