@article{b8b1a7a5e5fd44bcb6ec1a1ef53a682d,
title = "FOXA2 promotes prostate cancer growth in the bone",
abstract = "Bone metastasis frequently occurs in advanced-stage prostate cancer (PCa) patients. Understanding the mechanisms that promote PCa-mediated bone destruction is important for the identification of therapeutic targets against this lethal disease. We found that forkhead box A2 (FOXA2) is expressed in a subset of PCa bone metastasis specimens. To determine the functional role of FOXA2 in PCa metastasis, we knocked down the expression of FOXA2 in PCa PC3 cells, which can grow in bones and elicit an osteolytic reaction. The PC3/FOXA2-knockdown cells generated fewer bone lesions following intra-tibial injection compared to control cells. Further, we found that FOXA2 knockdown decreased the expression of PTHLH, which encodes PTHrP, a well-established factor that regulates bone remodeling. These results indicate that FOXA2 is involved in PCa bone metastasis.",
author = "Connelly, {Zachary M.} and Renjie Jin and Jianghong Zhang and Shu Yang and Siyuan Cheng and Mingxia Shi and Cates, {Justin M.M.} and Runhua Shi and DeGraff, {David J.} and Nelson, {Peter S.} and Yunlong Liu and Colm Morrissey and Eva Corey and Xiuping Yu",
note = "Funding Information: We would like to thank Dr. Robert Matusik at Vanderbilt University Medical Center and Dr. Michael Cher at Wayne State University for advice on the research. We thank the patients and their families, Celestia Higano, Evan Yu, Elahe Mostaghel, Heather Cheng, Bruce Montgomery, Paul Lange, Robert Vessella, Martine Roudier, Lawrence True, and the rapid autopsy teams for their contributions to the University of Washington Medical Center Prostate Cancer Donor Rapid Autopsy Program. This research is supported by the Department of Defense grant W81XWH-12-1-0212 and Prostate Cancer Biorepository Network grant W81XWH-14-2-0183, NIH R03 CA212567, U54 GM104940, the PNW Prostate Cancer SPORE P50 CA097186, P01 CA163227, LSUHSC FWCC and Office of Research funding to XY, and Carroll Feist Pre-doctoral Fellowship to ZC. Publisher Copyright: {\textcopyright} 2020 E-Century Publishing Corporation. All rights reserved. Copyright: Copyright 2020 Elsevier B.V., All rights reserved.",
year = "2020",
language = "English (US)",
volume = "12",
pages = "5619--5629",
journal = "American Journal of Translational Research",
issn = "1943-8141",
publisher = "e-Century Publishing Corporation",
number = "9",
}